As China's first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band (1-250 keV) slat-collimator-based X-ray astronomy satellite with the

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Bacteriophages (phages) are the most abundant and widely distributed organisms on Earth, constituting a virtually unlimited resource to explore the development of biomedical therapies. The therapeutic use of phages to treat bacterial infections (“phage therapy”) was conceived by Felix d’Herelle nearly a century ago. However, its power has been realized only recently, largely due to the emergence of multi-antibiotic resistant bacterial pathogens. Progress in technologies, such as high-throughput sequencing, genome editing, and synthetic biology, further opened doors to explore this vast treasure trove. Here, we review some of the emerging themes on the use of phages against infectious diseases. In addition to phage therapy, phages have also been developed as vaccine platforms to deliver antigens as part of virus-like nanoparticles that can stimulate immune responses and prevent pathogen infections. Phage engineering promises to generate phage variants with unique properties for prophylactic and therapeutic applications. These approaches have created momentum to accelerate basic as well as translational phage research and potential development of therapeutics in the near future.

The Insight-Hard X-ray Modulation Telescope (Insight-HXMT) is a broad band X-ray and gamma-ray (1-3000 keV) astronomy satellite. The High Energy X-ray telescope (HE) is one of its three main telescopes. The main detector plane of HE is composed of 18 NaI(Tl)/CsI(Na) phoswich detectors, where NaI(Tl) serves as primary detector to measure ~ 20-250 keV photons incident from the field of view (FOV) defined by the collimators, and CsI(Na) is used as an active shield detector to NaI(Tl) by pulse shape discrimination. CsI(Na) is also used as an omnidirectional gamma-ray monitor. The HE collimators have a diverse FOV: 1.1°x 5.7° (15 units), 5.7°x 5.7° (2 units) and blocked (1 unit), thus the combined FOV of HE is about 5.7°x 5.7°. Each HE detector has a diameter of 190 mm, resulting in the total geometrical area of about 5100 cm 2 . The energy resolution is ~15% at 60 keV. The timing accuracy is better than 10 μs and dead-time for each detector is less than 10 μs. HE is devoted to observe the spectra and temporal variability of X-ray sources in the 20-250 keV band either by pointing observations for known sources or scanning observations to unveil new sources, and to monitor the gamma-ray sky in 0.2-3 MeV. This paper presents the design and performance of the HE instruments. Results of the on-ground calibration experiments are also reported.

A black hole X-ray binary produces hard X-ray radiation from its corona and disk when the accreting matter heats up. During an outburst, the disk and corona co-evolves with each other. However, such an evolution is still unclear in both its geometry and dynamics. Here we report the unusual decrease of the reflection fraction in MAXI J1820+070, which is the ratio of the coronal intensity illuminating the disk to the coronal intensity reaching the observer, as the corona is observed to contrast during the decay phase. We postulate a jet-like corona model, in which the corona can be understood as a standing shock where the material flowing through. In this dynamical scenario, the decrease of the reflection fraction is a signature of the corona’s bulk velocity. Our findings suggest that as the corona is observed to get closer to the black hole, the coronal material might be outflowing faster.