Optofluidic, as an emerging technology that combines photons and microfluidics, has become a powerful, intelligent, and universal sensing platform in the field of bio-chemical sensing. Optical fiber optofluidic (OFOF), as a branch of optofluidic technology, has stimulated a host of remarkable achievements in the field of bio-chemical sensing due to its superiority of compact structure, immunity to electromagnetic interference, low sample consumption, high sensitivity, and real-time dynamic response. In this paper, an overview of OFOF bio-chemical sensors is presented. The OFOF system architectures are introduced and some advanced functional materials and coating technologies that can be utilized in the OFOF sensing platform to achieve high-performance biochemical sensing are summarized. Research progress and current status of OFOF bio-chemical sensors based on various sensing mechanisms are summarized and analyzed, with emphases on their sensing principles, sensing structures, sensing applications, advantages, and disadvantages. Lastly, the existing challenges and future development trends of OFOF biochemical sensors are briefly discussed.

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A multifunctional optical fiber sensor fabricated by asymmetric offset splicing is proposed in this Letter. The light is divided into several parts at the offset interface, among which the transmitted light forms the Mach–Zehnder interference (MZI) spectrum while the reflected light forms the Fabry–Perot interference (FPI) spectrum. The online monitoring system is built to create a better light distribution at the offset interface. Theoretical analysis and experimental verification are carried out. The results of the experiment show that the proposed sensor has good characteristics of salinity and temperature, and the salinity sensitivity is as high as − 2.4473 n m / ‰ in the range of 20–40‰; the temperature sensitivity is better than 2.17 nm/°C in the range of 28–48 °C. The two interferometers involved have different responses to temperature and salinity, contributing to the effective elimination of cross-sensitivity. The proposed optical fiber sensor has the benefits of compact size, high sensitivity, and multispectral measurement function.

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