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Functional materials from the microfluidic-based droplet community are emerging as enabling tools for various applications in tissue engineering and cell biology. The innovative micro- and nano-scale materials with diverse size,...

Fabrication and application of novel anisotropic microparticles are of wide interest. Herein, a new method for producing novel crater−terrain hydrogel microparticles is presented using a concept of droplet−aerosol impact and regional polymerization. The surface pattern of microparticles is similar to the widespread "crater" texture on the lunar surface and can be regulated by the impact morphology of aerosols on the droplet surface. Methodological applicability was demonstrated by producing ionic-cross-linked (alginate) and photo-cross-linked (poly-(ethylene glycol) diacrylate, PEGDA) microparticles. Additionally, the crater−terrain microparticles (CTMs) can induce nonspecific protein absorption on their surface to acquire cell affinity, and they were exploited as cell carriers to load living cells. Cells could adhere and proliferate, and a special cellular adhesion fingerprint was observed on the novel cell carrier. Therefore, the scalable manufacturing method and biological potential make the engineered microparticles promising to open a new avenue for exploring cell−biomaterial crosstalk.

Climate change and land use/cover change are altering the global hydrological cycle, leading to intensified water scarcity issues and rising risks of water-related natural hazards (e.g., floods and droughts) in many regions of the world (e.g., Cook et al., 2018;Konapala et al., 2020;Padrón et al., 2020). As a vital component of the terrestrial hydrological cycle, river streamflow is not only the most direct freshwater resource for various kinds of human needs but also an (if not the most) representative indicator of hydrological response to environmental changes at the catchment scale, since streamflow represents an integrated consequence of multiple hydrological processes and their interactions with climate and surface characteristics in a catchment (Zaitchik et al., 2010). Many studies have assessed the hydrological responses to global environmental changes using observed streamflow at the catchment and/or regional scales (e.g.,

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