Purpose: To measure and compare cortical and medullary T1 values in native and transplanted kidneys with a wide range of function as measured by estimated glomerular filtration rate (eGFR). Materials and Methods:A total of 27 subjects (12 native and 15 transplants) were studied. Two magnetic resonance imaging (MRI) exams of T1 measurement were performed on separate days for reproducibility study. Groupwise comparisons of renal T1 on day 1 were performed between subjects with native and transplanted kidneys and also between subjects based on an eGFR threshold of 60 mL/min/1.73m 2 .Results: Transplanted kidneys had higher cortical renal T1 (1183 6 136 msec) than native kidneys (1057 6 94 msec) with similar results in the medulla. Subjects with an eGFR < 60 mL/min/1.73m 2 had higher renal T1 than subjects with an eGFR > 60 mL/min/1.73m 2 (cortical T1: P < 0.0001; medullary T1: P ¼ 0.008). Renal T1 was highly reproducible for both native and transplant groups (with percent differences less than 10%).Conclusion: There are differences in cortical and medullary T1 between native and transplanted kidneys at different levels of function.

Background Heart failure (HF) is the end stage of most heart disease. Mesenchymal stem cells (MSCs), with their specific biological effects, have been applied in several clinical trials to evaluate the efficacy in HF therapy. We performed this meta-analysis to review the clinical evidence of their therapeutic effect on HF. Methods Three databases were searched. The outcomes of interest were death, readmission, the 6-min walk test (6MWT), New York Heart Association (NYHA) class and left ventricular ejection fraction (LVEF). The relative risk (RR) and weighted mean difference (WMD) were calculated to evaluate the effects of MSCs on HF compared to placebo. Results A total of nine studies were included, involving 612 patients who underwent MSCs or placebo treatment. The overall rate of death showed a trend of reduction of 36% (RR [CI] = 0.64 [0.35, 1.16], p = 0.143) in the MSC treatment group. The incidence of readmission was reduced by 34% (RR [CI] = 0.66 [0.51, 0.85], p = 0.001). The patients in the MSC treatment group realised an average of 40.44 m (WMD [95% CI] = 40.44 m [19.07, 61.82], p < 0.0001) improvement in 6MWT. The NYHA class was reduced obviously in the MSC group (WMD [95% CI] = − 0.42 [− 0.64, − 0.20], p < 0.0001). The changes of LVEF from baseline were significantly more than 5.25% (WMD [95% CI] = 5.25 [3.58, 6.92], p < 0.0001) in the MSCs group, unlike in the placebo group. Conclusions Our results suggested that MSC treatment is an effective therapy for HF by improving the prognosis and exercise capacity. SCs derived from allosomes have superior therapeutic effects, and intracoronary injection is the optimum MSC delivery approach. Short-term cryopreservation is feasible in MSCs storage or transport.

COVID-19 should not be the world's last public health disaster, so there is an urgent need to learn from COVID-19 to prepare better for the next public health disaster. This study aims to understand the factors that make people wear a face mask at the beginning of an outbreak of public health disaster. Semi-structured interviews were conducted during April 2020 in China, one month after the COVID-19 was declared a pandemic. The respondents were members of the public living in China, covering two age groups: young adults and older adults. They were recruited using a convenient sample and snowball sampling strategy. The results were analysed using content analysis. Seventeen subjects were recruited, among which nine were young adults (average age = 26.4; SD = 10.5), and eight were older adults (average age = 60.4; SD = 12.1). This study found that environmental factors, personal factors, factors concerning wearing masks, specific circumstances, and development of the pandemic were the common factors considered by both young adults and older adults. This study should help the authority formulate prevention policies better to reduce the risk of an outbreak if there is a new virus outbreak in the future, unfortunately.

This article examines the emerging phenomenon of the non-use of WeChat Moments. Drawing upon semi-structured interviews with 21 users who used Moments for at least 6 months, then voluntarily discontinued their use of the feature, we discuss the complex dynamics of Moments use, exploring the implicit micro-behavioral process of social media practice. Countering the purported hyper-centrality of WeChat, we identified a periodic loop of “use, non-use, reuse” of Moments, suggesting that people suspend their use of Moments periodically to “re-domesticate” technology. Through the prism of the domestication approach, we argue that the re-domestication of Moments is a “reboot” of the whole process of domestication through four key stages: re-appropriation, re-objectification, re-incorporation, and re-conversion. Re-domestication is a process that allows people to take a retrospective look at their lives and transform Moments from a disruptive app feature into an instrumental apparatus conducive to their personal and professional well-being. By examining this process, we discuss how people use innovative ways to regain their autonomy and agency in their daily interactions with WeChat.