A self-developed gas desorption and diffusion experimental system was used to conduct isothermal methane gas desorption and diffusion experiments, and the pore structure of coal samples was analyzed. A new mathematical model for gas diffusion in coal particles was established, and the diffusion coefficient was calculated using the new model. The influences of particle size and the adsorption equilibrium pressure on the methane gas diffusion rate, gas diffusion quantity, and diffusion coefficient were analyzed and discussed. The results show that under different adsorption equilibrium pressures and different particle sizes, the diffusion rate and quantity vary substantially. The larger the particle size, the slower the initial gas diffusion rate and the longer the time required to reach desorption equilibrium. The larger the adsorption pressure, the greater the initial gas diffusion rate and the larger the quantity of diffusion gas accumulated. However, the coal particle size has little influence on the amount of gas diffusion. It was found that as the particle size decreases, the diffusion coefficient in the first diffusion phase is significantly reduced, which decays with a negative exponential function over time. However, the adsorption equilibrium pressure has no obvious influence on the diffusion coefficient. In addition, the methane gas diffusion process was divided into three phases, namely, phase I, rapid diffusion phase (0-10 min); phase II, slow diffusion phase (10-100 min); and phase III, smooth diffusion phase (100 min); and the diffusion mechanism corresponding to each phase was analyzed. These research results provide a theoretical and practical reference value for gas prevention and control in coal mines. Keywords Gas desorption and diffusion . Mathematical model . Coal particle size . Adsorption equilibrium pressure . Diffusion coefficient . Three phases of gas diffusion This article is part of the Topical Collection on Mine Safety Science and Engineering Electronic supplementary material The online version of this article (

This article studies the influence of entrepreneurial spirit on college students’ entrepreneurial ability and entrepreneurial values. Firstly, the impact of entrepreneurial psychology and entrepreneurial spirit on entrepreneurial values is analyzed. Secondly, the role of entrepreneurial values in innovation and entrepreneurship education is analyzed and summarized under new media. Then, based on entrepreneurial psychology and entrepreneurial spirit, a Questionnaire Survey (QS) is designed to investigate the entrepreneurial values of students in one university in Shaanxi Province, China. The QS analysis suggests that most respondents hold a positive attitude, and their attitude is on the rise. The QS results of “Reasons for entrepreneurial failure” show that 40.37, 31.9, 25.98, and 11.75% of respondents think they lack financial support, business skills, ability, and understanding of policies and laws, respectively. The QS results of “What factors influence entrepreneurial values?” reveal that 39.43% of the respondents chose the “Models of successful entrepreneurs,” successful entrepreneur models can effectively encourage students to receive entrepreneurship education, followed by 28.94% who choose “Achieve their own life goals.” In terms of “Solutions against entrepreneurial risks,” nearly 70% of the students have chosen the negative options. In terms of “Which is the most important entrepreneurial quality?” more students choose entrepreneurial values rather than entrepreneurial quality, proving that students generally lack entrepreneurial values. Given these problems, corresponding countermeasures are put forward to strengthen entrepreneurial psychology and entrepreneurship education, in an attempt to cultivate college students’ entrepreneurial values and entrepreneurial ability under the new media. The results provide some data support for the impact of college students’ entrepreneurial values and entrepreneurial ability.

<p><span>Chemical processing of reactive nitrogen species, especially NO<sub>x</sub>(=NO+NO<sub>2</sub>) and nitrous acid (HONO), determines/alters critically the photochemical ozone production in the troposphere, affecting the climate change, biological cycle and human healthy. However, the characteristics and sources of nitrous acid (HONO) and NO<sub>x </sub>in the remote marine atmosphere are still poorly understood. Herein, based on the data sets of HONO-related species as well as other parameters measured during MarParCloud campaign at Cape Verde in October 2017, the multiphase chemistry model SPACCIM equipped with the state-of-the-art multiphase chemistry mechanism CAPRAM was adopted with input of current literature parametrizations for various HONO sources in the tropospheric boundary layer (gas reaction of NO and OH, ocean-surface-mediated conversion of NO<sub>2 </sub>to HONO, NO<sub>2 </sub>reacted with organics on mineral dust, NH<sub>3 </sub>oxidation process, and dust-surface-photocatalytic conversions of reactive nitrogen species to HONO) to reveal the relative importance of each source for HONO in the remote boundary layer at Cape Verde. Each simulation was performed for 72 hours in different clusters obtained from the backward trajectories model analysis with HYSPLIT. The simulations well reproduced the observed HONO level and its diurnal pattern, and significantly improved the model performance for NO<sub>x </sub>and O<sub>3 </sub>in every cluster after 72 hours of operation, when considering the mechanisms of dust-surface-photocatalytic conversions of reactive nitrogen species. Furthermore, photolysis of the absorbed HNO<sub>3 </sub>on the dust is modelled to be the prevailing contributor for the daytime HONO at Cape Verde, which accounted for about 56%, following by the photo-enhanced of NO<sub>2 </sub>absorbed on the dust (41%). In contrast, the ocean-surface-mediated conversion of NO<sub>2 </sub>to HONO and other pathways were found unimportant for HONO formation at Cape Verde. For OH sources, HONO photolysis only accounted for a small proportion source (~3%) of the ambient OH level in remote marine boundary layer due to the low HONO concentration at Cape Verde. In summary, this study highlights the key role of dust aerosols in the formation of HONO and NO<sub>x </sub>at Cape Verde.</span></p>

Objective This study aims to decode the proteomic signature of cardiomyocytes in response to lncRNA Ftx knockdown and overexpression via proteomic analysis, and to study the biological role of lncRNA Ftx in cardiomyocytes. Methods The expression level of the lncRNA Ftx in cardiomyocytes cultured in vitro was intervened, and the changes in protein levels in cardiomyocytes were quantitatively detected by liquid chromatography-mass spectrometry. The key molecules and pathways of the lncRNA-Ftx response were further examined by GO, KEGG, and protein interaction analysis. RESULTS A total of 2828 proteins are quantified. With a 1.5-fold change threshold, 32 upregulated proteins and 49 downregulated proteins are identified in the lncRNA Ftx overexpression group, while 67 up-regulated proteins and 54 down-regulated proteins are identified in the lncRNA Ftx knockdown group. Functional clustering analysis of differential genes revealed that the lncRNA Ftx is involved in regulating cardiomyocyte apoptosis and ferroptosis and improving cellular energy metabolism. In addition, Hub genes such as ITGB1, HMGA2, STAT3, GSS, and LPCAT3 are regulated downstream by lncRNA Ftx. Conclusion This study demonstrates that lncRNA Ftx plays a vital role in cardiomyocytes and may be involved in the occurrence and development of various myocardial diseases. It provides a potential target for clinical protection of the myocardium and reversal of myocardial fibrosis.

Objective This study aims to decode the proteomic signature of cardiomyocytes in response to lncRNA Ftx knockdown and overexpression via proteomic analysis, and to study the biological role of lncRNA Ftx in cardiomyocytes.  Methods The expression level of the lncRNA Ftx in cardiomyocytes cultured in vitro was intervened, and the changes in protein levels in cardiomyocytes were quantitatively detected by liquid chromatography-mass spectrometry. The key molecules and pathways of the lncRNA-Ftx response were further examined by GO, KEGG, and protein interaction analysis. Results A total of 2828 proteins are quantified. With a 1.5-fold change threshold, 32 upregulated proteins and 49 downregulated proteins are identified in the lncRNA Ftx overexpression group, while 67 up-regulated proteins and 54 down-regulated proteins are identified in the lncRNA Ftx knockdown group. Functional clustering analysis of differential genes revealed that the lncRNA Ftx is involved in regulating cardiomyocyte apoptosis and ferroptosis and improving cellular energy metabolism. In addition, Hub genes such as ITGB1, HMGA2, STAT3, GSS, and LPCAT3 are regulated downstream by lncRNA Ftx. Conclusion This study demonstrates that lncRNA Ftx plays a vital role in cardiomyocytes and may be involved in the occurrence and development of various myocardial diseases. It provides a potential target for clinical protection of the myocardium and reversal of myocardial fibrosis.