Multiple mononeuropathy is an unusual form of peripheral neuropathy involving two or more nerve trunks. It is a syndrome with many different causes. We reviewed the clinical, electrophysiological and nerve biopsy findings of 14 patients who suffered from multiple mononeuropathy in our clinic between January 2009 and June 2013. Patients were diagnosed with vasculitic neuropathy (n = 6), perineuritis (n = 2), chronic inflammatory demyelinating polyradiculoneuropathy (n = 2) or Lewis-Sumner syndrome (n = 1) on the basis of clinical features, laboratory data, electrophysiological investigations and nerve biopsies. Two patients who were clinically diagnosed with vasculitic neuropathy and one patient who was clinically diagnosed with chronic inflammatory demyelinating polyradiculoneuropathy were not confirmed by nerve biopsy. Nerve biopsies confirmed clinical diagnosis in 78.6% of the patients (11/14). Nerve biopsy pathological diagnosis is crucial to the etiological diagnosis of multiple mononeuropathy.
As promising adsorbents in carbon capture and storage, hyper-cross-linked polymers (HCPs) require high CO 2 uptake and selectivity over N 2 and CH 4 . Herein, we reported a series of novel carbonyl-incorporated HCPs using oxalyl chloride as a cross-linker. To enhance the CO 2 adsorption capacity and gas selectivity, the fabricated HCPs were further modified by methods of amine functionalization (HCPs-N) and KOH activated carbonization (HCPs-C). Accordingly, the maximum CO 2 adsorption capacity of HCPs (HCP3) reaches 198 mg/g owing to abundant carbonyl groups and dominant microporous structures (S BET 1047 m 2 /g, S micro 628 m 2 /g). Meanwhile, under the effect of amine functionalization, the selectivity of the obtained HCPs-N (HCP3-N) is greatly improved, reaching a maximum of 85.71 (SCO 2 /N 2 ) and 8.12 (SCO 2 /CH 4 ). Furthermore, after KOH activated carbonization, the amount of CO 2 adsorption of HCPs-C (HCP3-C) significantly increases to 270 mg/g due to the higher specific surface area (S BET 1421 m 2 /g) and arising ultramicroporous structures (V ultra 0.26 cm 3 /g). Aromatic polymers with microporous structures and carbonyl group can be prepared and functionalized to improve the CO 2 adsorption and gas selectivity by simple and mild reactions. Our study provides new options for CO 2 capture of HCPs and provides a new idea for the synthesis of new HCPs.
Charcot-Marie-Tooth disease type 1A (CMT1A) is caused by duplication of the peripheral myelin protein 22 (PMP22) gene on chromosome 17. It is the most common inherited demyelinating neuropathy. Type 2 diabetes mellitus is a common metabolic disorder that frequently causes predominantly sensory neuropathy. In this study, we report the occurrence of CMT1A in a Chinese family affected by type 2 diabetes mellitus. In this family, seven individuals had duplication of the PMP22 gene, although only four had clinical features of polyneuropathy. All CMT1A patients with a clinical phenotype also presented with type 2 diabetes mellitus. The other three individuals had no signs of CMT1A or type 2 diabetes mellitus. We believe that there may be a genetic link between these two diseases.
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