Protein ubiquitination is a posttranslational modification that plays an integral part in mediating diverse cellular functions. The process of protein ubiquitination requires an enzymatic cascade that consists of a ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2) and an E3 ubiquitin ligase (E3). There are an estimated 600–700 E3 ligase genes representing ~5% of the human genome. Not surprisingly, mutations in E3 ligase genes have been observed in multiple neurological conditions. We constructed a comprehensive atlas of disrupted E3 ligase genes in common (CND) and rare neurological diseases (RND). Of the predicted and known human E3 ligase genes, we found ~13% were mutated in a neurological disorder with 83 total genes representing 70 different types of neurological diseases. Of the E3 ligase genes identified, 51 were associated with an RND. Here, we provide an updated list of neurological disorders associated with E3 ligase gene disruption. We further highlight research in these neurological disorders and discuss the advanced technologies used to support these findings.

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For collaborative environments to be successful, it is critical that participants have the ability to generate effective references. Given the heterogeneity of the objects and the myriad of possible scenarios for collaborative augmented reality environments, generating meaningful references within them can be difficult. Participants in co-located physical spaces benefit from non-verbal communication, such as eye gaze, pointing and body movement; however, when geographically separated, this form of communication must be synthesized using computer-mediated techniques. We have conducted an exploratory study using a collaborative building task of constructing both physical and virtual models to better understand inter-referential awarenessor the ability for one participant to refer to a set of objects, and for that reference to be understood. Our contributions are not necessarily in presenting novel techniques, but in narrowing the design space for referencing in collaborative augmented reality. This study suggests collaborative reference preferences are heavily dependent on the context of the workspace.