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Background: The triglyceride glucose index (TyG index), a reliable alternative marker of insulin resistance (IR), has been regarded as an independent predictor of cardiovascular disease (CVD). However, the relationship between TyG index and coronary artery disease (CAD) in premenopausal women remains unclear. We aimed to investigate the prognostic value of TyG index in premenopausal women with CAD. Methods: A total of 158 Chinese female subjects were enrolled in this retrospective study. Clinical data were collected from medical records. The severity of CAD was assessed by coronary angiography. CAD was defined as Coronary artery stenosis ≥50% in at least one major coronary artery. Patients were divided into different groups according to their TyG index and whether they had CAD. Multivariate logistic regression model was used to evaluate the relationship between TyG index and CAD. Results: The patients with high TyG index had a higher risk of CAD than those with low TyG index (P<0.01). The difference was pronounced in the age group of 49 years or older. Multivariate logistic regression analysis showed that the TyG index was an independent risk factor for CAD in premenopausal women (fully adjusted model: OR 2.730, 95%CI 1.102-6.764, P=0.030). Conclusions: Elevated TyG index is associated with increased risk of CAD in Chinese premenopausal women, suggesting that the TyG index may be used as a marker of CAD risk in premenopausal women in China.

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