This study reports a revised method for determination of the conditional stability constant (K c ) and the equilibrium metal-to-ligand molar ratio (n) for various metal-dendrimer complexes. The method employs a system containing an ion-exchange resin, a dendrimer, and a metal (Cu 2+ or Pb 2+ ) solution. It considers the multi-dentate nature of dendrimers and employs a nonlinear (Langmuir) isotherm model to interpret the ion exchange isotherm. For its minimal dendrimer uptake, a weak acid cation-exchange resin, IRC-50, was found most suitable for the study. For complexes of Cu 2+ with a homologue of dendrimers with NH 2 terminal groups K c increased from 10 16.2 to 10 36.6 , and n increased from 1 to 13 as the generation number rose from 0.0 to 4.0. K c for complexes of Pb 2+ with a generation-1 dendrimer with NH 2 terminal groups was 10 17.2 at pH 5, compared to 10 20.9 for complexes of Pb 2+ with a generation-1.5 dendrimer with carboxylate terminal groups.