Purpose: Chinese herbal medicine (CHM) is an important complementary and alternative therapy for the management of irritable bowel syndrome (IBS). Previous meta-analyses suggested that CHM is effective for IBS; nonetheless, its effectiveness is inconclusive owing to repeated significance testing. We aimed to examine the efficacy and safety of CHM for IBS through a meta-analysis and trial sequential analysis (TSA).Methods: We searched OVID Medline, Embase, Cochrane Central Register of Controlled Trials, and Web of Science from January 1, 1980, to September 20, 2020. The primary outcome was adequate relief of global IBS symptoms. The secondary outcomes included relief of abdominal pain and treatment-related adverse events. The relative ratio (RR) and required information size (RIS) were calculated for each outcome.Results: Ten trials recruiting 2,501 participants were included. Seven (70%) trials were at low risk of bias (RoB). Compared with placebo, CHM was associated with a significantly higher proportion of adequate relief of global IBS symptoms [RR 1.76 (95% confidence interval (95%CI), 1.33–2.33); I2 = 81.1%; p < 0.001]. The RIS was 1,083 for the primary outcome, and the accrued information size was 1,716. The analysis of the relief of abdominal pain (three trials with 916 participants) showed similar results compared with placebo [RR 1.85 (95%CI, 1.59–2.14); I2 = 0%; p < 0.001; RIS = 197 participants]. CHM was associated with a higher proportion of adverse events compared with placebo [RR 1.51 (95%CI, 1.14–2); I2 = 0%; p = 0.004].Conclusion: CHM was effective in relieving IBS symptoms but caused a higher adverse event rate than placebo. TSA analysis confirmed the findings with sufficient information size.

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Background: Acute lumbar sprain is a common cause of acute low back pain. Motion style acupuncture treatment (MSAT; a combination of acupuncture and motion therapy) has been used for patients with acute lumbar sprain, but evidence of its efficacy is inconsistent. The aim of this systematic review with meta-analysis is to determine the effectiveness and security of motion style acupuncture treatment (MSAT) for acute lumbar sprain and to determine whether long-term effectiveness exists.Methods: Eight databases will be searched, including PubMed, SoniMed, Cochrane Library, EMBAS, Springer, China National Knowledge Infrastructure, Wanfang date, and Chinese Biomedical Literature Database from inception to February 1, 2021, will be restricted to English and Chinese. Methodologic quality was independently screened and graded by two blind reviewers using the Cochrane Collaborative bias risk tool. Meta-analysis was performed in at least three studies, and sub-group and sensitivity analyses were conducted when I2>50%. When the quantitative evaluation is not available, we will provide a qualitative description of the results of the individual study.Discussion: The conclusion of this protocol will provide evidence to judge the potential benefits of motion style acupuncture and conduct clinical decision-making for acute lumbar sprain treatment.Systematic review registration: A protocol had been registered in PROSPERO CRD42020192876.

Neurogenic intestinal care is currently a major research topic in the medical field. In order to improve the accuracy of neurogenic intestinal care and simplify the process of neurogenic intestinal care, this paper adopts a three-dimensional analysis theory to extract the key indicators in neurogenic intestinal care. Through the analysis and calculation of the test data, the calculation results of neurogenic intestinal care under the effect of three-dimensional reconstruction technology were obtained. Through the analysis of the results, the calculation law under the action of the optimization model can be obtained. Based on the three-dimensional reconstruction theory, the contents of neurogenic intestinal care were analyzed by the three-dimensional reconstruction de-highlighting algorithm. The three-dimensional curve was used to screen the key indicators of neurogenic intestinal care, so as to obtain the optimized heavy weight model, and the three-dimensional reconstruction model can analyze the indicators of neurogenic intestinal care. It can be seen from relevant studies that different indicators have different trends in their range of change in the curve projection diagram of the 3D curve screening method. Among them, the curve shadow and curve point have obvious downward changes, while the curve deviation has U-shaped changes. The range of curve weights is relatively large. The variation rule between different data in the 3D curve segment can be obtained through the cost function. Among them, the cost function index and the cost model parameter have the same change trend, and the overall fluctuation range is relatively small through the space index. In the calculation results of neurogenic intestinal care, different factors will have a great influence on the calculation results. Neurons and intestinal peristalsis have the same change trend, while the linear characteristics of nerve endings are relatively obvious, and the fluctuation characteristics of gastrointestinal digestion are good. The health standard decreases linearly with the increase of the sample, and the dynamic reconstruction has a positive effect on the data. This study can provide research ideas for the analysis of neurogenic gut.

Background: As one of the important manifestations of neurogenic bowel dysfunction, constipation is characterized by high incidence and harmful effects. It has a negative impact on both physical and psychological health of patients. And there are no effective treatment options for this type of disease clinically. Therefore, this study is designed to examine the effect of the therapy of “combination 3 methods progression” in patients with neurogenic bowel dysfunction (constipated type). Methods: This is a randomized, controlled, parallel-design clinical trial. A total of 60 patients with neurogenic bowel dysfunction (constipated type) will be randomly assigned to intervention group and control group. The control group will receive 4 weeks of usual rehabilitation care, the intervention group will receive 4 weeks of the therapy of “combination 3 methods progression” in addition to usual rehabilitation care. The primary outcome is the number of spontaneous bowel movement per week. Secondary outcomes are stool characteristics, degree of difficulty in defecation, level of anxiety, level of depression, and level of self-efficacy. Discussion: The interventions of this protocol have been programmed to alleviate constipation in patients with neurogenic bowel dysfunction. Findings may provide preliminary evidence for clinical efficacy of the therapy of “combination 3 methods progression.” Trial registration: Chinese Clinical Trial Registry, IDF: ChiCTR2000041463. Registered on December 26, 2020.