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Background: There are no clear expert consensus or guidelines on how to treat 2019 coronavirus disease . The objective of this study is to investigate the short-term effect of risk-adapted treatment strategy on patients with COVID-19. Methods: We collected the medical records of 55 COVID-19 patients for analysis. We divided these patients into mild, moderate and severe groups, and risk-adapted treatment approaches were given according to the illness severity. Results: Twelve patients were in mild group and 22 were in moderate group (non-severe group, n = 34), and 21 patients were in severe group. At the end of the first two weeks after admission, clinical manifestations had completely despeared in 31(91.2%)patients in non-severe group, and 18(85.7%) patients in severe group (p = 0.85). Both groups had a satisfied chest CT imaging recovery, which includes 22(64.7%) patients in non-severe group and 12(57.1%) patients in severe group recovered at least 50% of the whole leisions in the first week, and 28(82.4%) and 16(76.2%) recovered at least 75% in the second week, respectively. There were no significant differences in SARS-CoV-2 nucleic acid negativity (p = 0.92). There were also no significant differences in the levels of SARS-CoV-2-IgM and IgG antibody production between the two groups (p = 0.13, 0.62). There were 45 cases were discharged from the hospital, and no patients died at the time of this clinical analysis. Conclusions: Risk-adapted treatment strategy was associated with significant clinical manifestations alleviation and clinical imaging recovery. In severe COVID-19 patients, early and short-term use of lowdose methylprednisolone was beneficial and did not delay SARS-CoV-2 nucleic acid clearance and influence IgG antibody production.

To boost the use of electronic devices and driving mileage of electric vehicles, it is urgent to develop lithium-ion batteries (LIBs) with higher energy density and longer life. High-voltage and high-capacity cathode materials, such as LiCoO 2 , LiNi 0.5 Mn 1.5 O 4 , Ni-rich layered oxides, and lithium-rich layered oxides, are critically important for LIBs to obtain high energy density. Among various forms of these materials, "single-crystal" cathodes (SCCs) have shown many advantages over other forms for industrial applications, including good crystallinity, high mechanical strength, high reaction homogeneity, small specific surface area, excellent structural stability, and high thermal stability, which can noticeably improve the cycling performance and safety of SCCbased batteries. Therefore, SCCs have received wide attention from academic to industrial communities and have been applied to the liquid-based and solid-state batteries in recent years. In this paper, the advantages, progress, and challenges of SCCs for highvoltage cathode materials are reviewed. Moreover, we summarize the efforts for improving the electrochemical performance of SCCs, intending to provide insights into the development of high-performance cathodes for practical LIBs.

• Digital breast tomosynthesis has high sensitivity and specificity in breast diagnosis.• DBT appears to have superior diagnostic accuracy relative to digital mammography. • DBT images were captured at a lower dose than 2D images. • DBT displays abnormal features of lesions more clearly than DM. • Digital breast tomosynthesis could become the first choice for assessing breast lesions.