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Background: Micro-albuminuria has been extensively regarded as a marker of generalized vascular endothelial impairment. Endothelial dysfunction is an early marker for atherosclerosis and can be detected before structural changes to the vessel wall.Methods: This case control study was carried out in the Department of Medicine, MGM Medical College and MY Hospital, Indore, India, from December 2017 to February 2019, with sample size of 100 including 50 cases and 50 controls.Results: In our study, mean CIMT of cases and controls was 0.83±0.10mm and 0.63±0.14mm in right respectively. Mean CIMT of cases and controls was 0.83±0.10 and 0.64±0.07mm in left side respectively. These results are suggestive that mean CIMT are significantly higher (p values <0.05 in each) in cases than controls. 90% of cases were in stage II of CKD and their mean CIMT was 0.83±0.09mm and 10% of cases were in stage I of CKD and their mean CIMT was 0.80±0.09mm and there were no significant difference in mean CIMT between CKD stage I and CKD stage II in cases. There were significant positive correlation between Mean CIMT and Age of cases (Pearson correlation=0.382, p-value 0.006).Conclusions: Increased CIMT was found in all the cases as compare to controls so, increased CIMT can be used as an early marker of atherosclerosis in early CKD patients. Further study in large number of subjects may help to confirm or exclude the findings.

Background: Presence of overt proteinuria has been independently linked to greater stroke risk. The objectives of this study were to determine the relationship between the for ischemic stroke and albuminurea as a marker for vascular events. Microalbuminuria, is an early marker of both kidney disease and endothelial dysfunction, may be associated with global vascular risk, but the nature and relationship between microalbuminuria and incident ischemic stroke has not been clearly defined. The purpose of this study was to assess the association of microalbuminuria and ischemic stroke.Methods: Study enrolled 150 admitted patients of acute ischemic stroke. The patients were assessed by questionnaire, microalbuminuria, creatinine clearance after detailed history taking and thorough clinical examination.Results: The combined common risk factors were HTN (80%), diabetes (33%) and smoking (53%). The hypertensive patients had 8 times higher risk of microalbuminuria as compared to normotensive patients (95% 1.8-31.0 p<0.05). Among diabetes patients had risk of microalbuminuria 30 times higher compared to euglycemic patients (95% CL 9.6-78.8 p<0.01). The smoker patients had 8 times risk of microalbuminuria (CL 95%-1.2-22.8 p<0.16). However, the patients who had dyslipidemia had risk of microalbuminuria 1.07 times who have normal lipid level, but it was statistically insignificance (98% CL 0.8-4.1 p>0.05). The 38 patients out of 46 patients who had microalbuminuria has high normal serum creatinine with creatinine clearance (45-59 mL/min/1.73 m2. (82% versus. 4.4% 30.44 mL/min/173m2). The risk of microalbuminuria was higher in patients who had high normal serum creatinine (1.4 mg/dL) with creatinine clearance of 45-59 mL/min/1.73 m2 versus normal serum creatinine 0.8 mg/dL.Conclusions: The finding of the study, show the microalbuminuria is an independent risk factor for vascular endothelial dysfunction, in patient of diabetes early renal dysfunction and HTN, extrapolating the vascular event (ischemic stroke).