Objective:The objective of this study is to evaluate the comparative effect of curcumin and ornidazole in treating chronic periodontitis.Materials and Methods:Twenty individuals of both sexes aged between 27 and 53 years diagnosed with chronic periodontitis and having pocket depths >5 mm bilaterally were selected for this study, in a split-mouth design. Examination of plaque index, probing pocket depth, and clinical attachment level was measured for each patient. The patients received a complete prophylaxis including scaling and root planing after which, both test gels were injected into the two experimental sites chosen, that had probing depth (PD) >5 mm and were located in symmetric quadrants. Pocket PD, clinical attachment loss, and plaque index were recorded at days 0 and 30.Results:At 1-month evaluation, curcumin group showed a significant decrease in pocket PD, plaque index, and clinical attachment loss when compared to the ornidazole group.Conclusion:The results show a more favorable outcome with curcumin than ornidazole gel, thus curcumin can be used as an adjunct to nonsurgical periodontal therapy.

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Transient bacteremias are detected frequently following dental manipulations. Infective endocarditis (IE) can be seen in susceptible individuals and antibiotic prophylaxis can be prescribed for certain procedures considered to be at risk of IE. There are evidences that periodontal disease may be a significant risk factor for the development of certain systemic diseases, such as cardiovascular disease. Initiated by the bacteria into the bloodstreams, these systemic conditions are detrimentally influenced by the bacterial ingrowth.