Under general anaesthesia even in elective operative procedure, there are chances of aspiration of gastric contents resulting in acid aspiration syndrome. H2 antagonists Ranitidine and Proton Pump Inhibitors were evaluated to compare efficacy of the drugs in decreasing gastric volume and increasing gastric pH when administered orally overnight and early in the morning; 250 patients of ASA grade I and II of either sex were divided in 5 equal Groups of 50 patients each. Group I patients received Tab. Placebo, Group II received Tab. Ranitidine 150 mg, Group III received Tab. Omeprazole 20 mg, Group IV received Tab. Pantoprazole 40 mg and