Lampung is one of the provinces in Indonesia that feels the impact of regional autonomy, so a measuring tool is needed to determine the economic condition per period through gross regional domestic product. The purpose of this study is to determine the effect of Regional Original Income, General Allocation Funds, and Special Allocation Funds on GRDP. This study uses a quantitative approach. The type of data used is secondary data found on the official website of BPS Lampung. The type of data used is time series data in the 2016-2018 period and cross section data for 15 districts/cities in Lampung Province. The statistical analysis method used is multiple linear regression analysis, using the SPSS 20 program. The results of the analysis conclude that: Regional Original Income has a positive effect on GRDP, General Allocation Funds have a positive effect on GRDP, and the Special Allocation Fund K has no effect and is negative on GRDP. GRDP. Simultaneously, the variables of Regional Original Revenue, General Allocation Fund, and Special Allocation Fund have a significant effect on GRDP.