Objectives Diabetes Mellitus (DM) is a group of insulin metabolism disorder that affects the socio-economic conditions of the community. The cost of treating diabetes in 2019 was USD 760 billion and by 2045 there are predicted to be 700 million people living with diabetes. The purpose of this systematic review was to provide an overview of the economic burden caused by Diabetes Mellitus for the government, health care providers, and for the community. Methods This systematic review was carried out by considering the related studies about the cost of illness, evaluation of disease costs, or therapeutic costs for various types of diabetes mellitus that were published in both English and Indonesian. The search engines PUBMED, DOAJ, SCOPUS, SCIENCE DIRECT, and GOOGLE SCHOLAR were used without date published restrictions. Results A systematic search identifies 18 eligible studies conducted in various regions in Indonesia. The study was retrospective with variation in their perspectives and methods to estimate the diabetes cost. Drug cost was the major contributor to direct medical cost followed by complications cost while other cost was affected by transportation cost, productivity losses, and time spent by family accompanying patients. Conclusions Diabetes mellitus creates a significant financial burden and affects the health care system as well as the individual and society as a whole. Research about the cost of diabetes in the future should be carried out on a large scale in order to get a more specific cost estimation.

Introduction: The high prevalence and incidence of complications due to diabetes mellitus impose an economic burden on patients and society. Aim: To obtain an overview of the cost of diabetes mellitus with complications and identify the factors that affect it. Methods: This study was conducted based on the perspective of health care providers. Results: The cost of illness for diabetes mellitus with complications was IDR 2,654,047,597 and an average cost of IDR 15,688,528/patient. Diabetes mellitus type 2 with peripheral circulation complications (E11.5) had the highest average cost (IDR 34,135,284/patient). The factors that significantly influenced direct medical costs were the length of stay, class of hospitalisation, and type of complications (Charlson comorbidity index). Conclusion: The results of this study indicate that the presence of complications increases the cost of diabetes mellitus treatment.