A 45‐year‐old housewife sustained a blow to the occipital region In a traffic accident about 2 years and 3 months prior to death. Autopsy revealed lesions of softening in the hypothalamus, left thalamus, frontal lobe (especially on the left), and base of the left temporal lobe. Following the head trauma, a marked Increase of appetite was noted, with obesity, hypogonadism, and mild elevation of temperature. No diabetes insipidus was noted whatsoever. Based on data from physical and pathological examination, the relationship between function and morphology in the human hypothalamus was discussed.

Marked fatty liver was noted as a common finding In a 24‐year‐old housewife with diabetes Insipidus and autopsy findings of infiltration of carcinoma of the superior pharynx to hypothalamus, and in a 45‐year‐old housewife with marked hyperorexla, obesity and autopsy findings of encephalomalacia of the hypothalamus. According to animal experiments and case reports available, fatty liver due to hypothalamic lesions may occur as a rare possibility.