Office buildings in Egypt require expensive cooling systems, which leads to significant increase in energy consumption in summer. Rising energy prices led to the need for turning to performance assessment tools to evaluate and improve buildings energy performance. There are various world-known rating systems such as Passive House (PH), LEED and BREEAM. While, this research focuses on PH standards considered nowadays to be the most rigorous voluntary energy-based standards in building. This research aims at investigating applicability and effectiveness of using PH standards to achieve energy-efficient performance and improve thermal comfort of office buildings in Egypt. Likewise, energy performance in three office buildings in Egypt was analyzed by e-QUEST simulation. One of the buildings is a new office building in CFC, the second is AEC office building, and the last building is Egypt Tours Tower. New planned office buildings in this research have been designed using PH standards and principles, as well, cost would be looked at to determine whether PH criteria is viable in Egypt. Evaluation of new proposed buildings was done by PH standards. However, final conclusions were that PH standards can be used to achieve energy-efficient performance of medium-rise office buildings in Egypt.