Purpose A real‐time solar cell based in vivo dosimetry system (SC‐IVD) was developed using a flexible thin film solar cell and scintillating powder. The present study evaluated the clinical feasibility of the SC‐IVD in electron beam therapy. Methods A thin film solar cell was coated with 100 mg of scintillating powder using an optical adhesive to enhance the sensitivity of the SC‐IVD. Calibration factors were obtained by dividing the dose, measured at a reference depth for 6–20 MeV electron beam energy, by the signal obtained using the SC‐IVD. Dosimetric characteristics of SC‐IVDs containing variable quantities of scintillating powder (0–500 mg) were evaluated, including energy, dose rate, and beam angle dependencies, as well as dose linearity. To determine the extent to which the SC‐IVD affected the dose to the medium, doses at R90 were compared depending on whether the SC‐IVD was on the surface. Finally, the accuracy of surface doses measured using the SC‐IVD was evaluated by comparison with surface doses measured using a Markus chamber. Results Charge measured using the SC‐IVD increased linearly with dose and was within 1% of the average signal according to the dose rate. The signal generated by the SC‐IVD increased as the beam angle increased. The presence of the SC‐IVD on the surface of a phantom resulted in a 0.5%–2.2% reduction in dose at R90 for 6–20 MeV electron beams compared with the bare phantom. Surface doses measured using the SC‐IVD system and Markus chamber differed by less than 5%. Conclusions The dosimetric characteristics of the SC‐IVD were evaluated in this study. The results showed that it accurately measured the surface dose without a significant difference of dose in the medium when compared with the Markus chamber. The flexibility of the SC‐IVD allows it to be attached to a patient's skin, enabling real‐time and cost‐effective measurement.

Purpose:The amount of luminescent light detected in a scintillator is reduced with increased proton linear energy transfer (LET) despite receiving the same proton dose, through a phenomenon called quenching. This study evaluated the ability of a solar cell coated with scintillating powder (SC-SP) to measure therapeutic proton LET by measuring the quenching effect of the scintillating powder using a solar cell while simultaneously measuring the dose of the proton beam. Methods: SC-SP was composed of a flexible thin film solar cell and scintillating powder. The LET and dose of the pristine Bragg peak in the 14 cm range were calculated using a validated Monte Carlo model of a double scattering proton beam nozzle. The SC-SP was evaluated by measuring the proton beam under the same conditions at specific depths using SC-SP and Markus chamber. Finally, the 10 and 20 cm range pristine Bragg peaks and 5 cm spread-out Bragg peak (SOBP) in the 14 cm range were measured using the SC-SP and the Markus chamber. LETs measured using the SC-SP were compared with those calculated using Monte Carlo simulations. Results:The quenching factors of the SC-SP and solar cell alone, which were slopes of linear fit obtained from quenching correction factors according to LET, were 0.027 and 0.070 µm/keV (R 2 : 0.974 and 0.975). For pristine Bragg peaks in the 10 and 20 cm ranges, the maximum differences between LETs measured using the SC-SP and calculated using Monte Carlo simulations were 0.5 keV/µm (15.7%) and 1.2 keV/µm (12.0%), respectively. For a 5 cm SOBP proton beam, the LET measured using the SC-SP and calculated using Monte Carlo simulations differed by up to 1.9 keV/µm (18.7%). Conclusions: Comparisons of LETs for pristine Bragg peaks and SOBP between measured using the SC-SP and calculated using Monte Carlo simulations indicated that the solar cell-based system could simultaneously measure both LET and dose in real-time and is cost-effective.

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