Summary The bio-based lactic acid (LA) and the common metal ion chelating agent iminodiacetic acid (IDA) are used to design and prepare a polymeric sustained-release Pb 2+ chelating agent by a brief one-step reaction. After the analysis on theoretical calculation for this reaction, poly(lactic acid-iminodiacetic acid) [P(LA- co -IDA)] with different monomer molar feed ratios is synthesized via direct melt polycondensation. P(LA- co -IDA) mainly has star-shaped structure, and some of them have two-core or three-core structure. Thus, a possible mechanism of the polymerization is proposed. The degradation rate of P(LA- co -IDA)s can reach 70% in 4 weeks. The change of IDA release rate is consistent with the trend of the degradation rate, and the good Pb 2+ chelating performance is confirmed. P(LA- co -IDA) is expected to be developed as a lead poisoning treatment drug or Pb 2+ adsorbent in the environment with long-lasting effect, and this research provides a new strategy for the development of such drugs.

Organic thioethers play an important role in the discovery of drugs and natural products. However, the green synthesis of organic sulfide compounds remains a challenging task. The convenient and efficient synthesis of 5-alkoxy-3-halo-4-methylthio-2(5H)-furanones from DMSO is performed via the mediation of 1,3-dibromo-5,5-dimethylhydantoin (DBDMH), affording a facile route for the sulfur-functionalization of 3,4-dihalo-2(5H)-furanones under transition metal-free conditions. This new approach has demonstrated the functionalization of non-aromatic Csp2-X-type halides with unique structures containing C-X, C-O, C=O and C=C bonds. Compared with traditional synthesis methods using transition metal catalysts with ligands, this reaction has many advantages, such as the lower temperature, the shorter reaction time, the wide substrate range and good functional group tolerance. Notably, DMSO plays multiple roles, and is simultaneously used as an odorless methylthiolating reagent and safe solvent.

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A facile route for the synthesis of benzodisulfide heterocyclic compounds via a NaHCO3‐promoted three‐component reaction between 2‐halophenylacetic acids, elemental sulfur (S8) and amines under metal‐free conditions has been demonstrated. This transformation from available starting materials shows good functional group tolerance, and the target compounds can be derivatized for further application.

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