No abstract

In this study, we show that robust and tunable acoustic asymmetric transmission can be achieved through gradient-index metasurfaces by harnessing judiciously tailored losses. We theoretically prove that the asymmetric wave behavior stems from loss-induced suppression of high order diffraction. We further experimentally demonstrate this novel phenomenon. Our findings could provide new routes to broaden applications for lossy acoustic metamaterials and metasurfaces.

This paper reports on the experimental observation of topologically protected edge state and exceptional point in an open and Non-Hermitian system. While the theoretical underpinning is generic to wave physics, the simulations and experiments are performed for an acoustic system whose structure has non-trivial topological properties that can be characterized by the Chern number provided that a synthetic dimension is introduced. Unidirectional reflectionless propagation, a hallmark of exceptional point, is unambiguously observed in both simulations and experiments. arXiv:1803.04110v1 [cond-mat.mes-hall]

Homeobox (HOX) genes encode a family of transcription factors, which play crucial roles in numerous processes, and their dysregulation is involved in the carcinogenesis of many human cancers. In the present study, we investigated the roles of HOXC8 in non-small cell lung cancer (NSCLC). We showed that HOXC8 was upregulated in clinical NSCLC specimens compared to normal lung tissues, and the high expression of HOXC8 correlated with tumor node metastasis (TNM) stage, tumor status, lymph nodal status and poor relapse-free survival for lung cancer patients. Functionally, HOXC8 expression significantly promoted the proliferation, anchorage-independent growth and migration of NSCLC, and HOXC8 functioned as a transcription activator to induce the expression of TGFβ1, leading to an increase in the proliferation, anchorage-independent growth and migration of NSCLC. Furthermore, we demonstrated that HOXC8 expression was associated with chemoresistance and anti-apoptosis in NSCLC, suggesting that HOXC8 is a promising therapeutic target for chemosensitization of NSCLC to cisplatin. Altogether, our study defined a critical role of HOXC8 in promoting transcription of TGFβ1 and NSCLC tumorigenesis.