AKARI, the first Japanese satellite dedicated to infrared astronomy, was launched on 2006 February 21, and started observations in May of the same year. AKARI has a 68.5 cm cooled telescope, together with two focal-plane instruments, which survey the sky in six wavelength bands from mid–to far-infrared. The instruments also have a capability for imaging and spectroscopy in the wavelength range 2-180$\mu$m in the pointed observation mode, occasionally inserted into a continuous survey operation. The in-orbit cryogen lifetime is expected to be one and a half years. The All-Sky Survey will cover more than 90% of the whole sky with a higher spatial resolution and a wider wavelength coverage than that of the previous IRAS all-sky survey. Point-source catalogues of the All-Sky Survey will be released to the astronomical community. Pointed observations will be used for deep surveys of selected sky areas and systematic observations of important astronomical targets. These will become an additional future heritage of this mission.

The development of a water oxidation catalyst has been a demanding challenge for the realization of overall water-splitting systems. Although intensive studies have explored the role of Mn element in water oxidation catalysis, it has been difficult to understand whether the catalytic capability originates mainly from either the Mn arrangement or the Mn valency. In this study, to decouple these two factors and to investigate the role of Mn valency on catalysis, we selected a new pyrophosphate-based Mn compound (Li2MnP2O7), which has not been utilized for water oxidation catalysis to date, as a model system. Due to the monophasic behavior of Li2MnP2O7 with delithiation, the Mn valency of Li(2-x)MnP2O7 (x = 0.3, 0.5, 1) can be controlled with negligible change in the crystal framework (e.g., volume change ~1%). Moreover, inductively coupled plasma mass spectrometry, X-ray photoelectron spectroscopy, ex-situ X-ray absorption near-edge structure, galvanostatic charging-discharging, and cyclic voltammetry analysis indicate that Li(2-x)MnP2O7 (x = 0.3, 0.5, 1) exhibits high catalytic stability without additional delithiation or phase transformation. Notably, we observed that, as the averaged oxidation state of Mn in Li(2-x)MnP2O7 increases from 2 to 3, the catalytic performance is enhanced in the series Li2MnP2O7 < Li(1.7)MnP2O7 < Li(1.5)MnP2O7 < LiMnP2O7. Moreover, Li2MnP2O7 itself exhibits superior catalytic performance compared with MnO or MnO2. Our study provides valuable guidelines for developing an efficient Mn-based catalyst under neutral conditions with controlled Mn valency and atomic arrangement.

We have carried out a survey toward the central regions of 85 starless cores in HCN(J ¼ 1 0) to study inward motions in the cores. Sixty-four cores were detected with HCN lines. The infall asymmetry in the HCN spectra is found to be more prevalent, and more prominent than in any other previously used infall tracers such as CS(J ¼ 2 1), DCO þ (J ¼ 2 1), and N 2 H þ (J ¼ 1 0). We have found a close relation between the intensities of the HCN and N 2 H þ lines. This implies that the HCN is not very depleted in the central regions of the cores. In some cores, the HCN spectra show different signs of asymmetry than other molecular lines. A few cores show various signs of asymmetry in individual HCN hyperfine lines. The distribution of the velocity shift V of the HCN profiles with respect to the systemic velocity of the optically thin tracer is found to be more shifted toward the bluer side than those of other infall tracers, indicating that the HCN traces inward motions more frequently. The V distribution of each HCN hyperfine line for all sources is similar. Moreover, the V values obtained from different HCN hyperfine lines for each source are nearly similar. These may mean that most starless cores are in similar kinematic states across the layers of the cores. We identify 17 infall candidates using all available indicators such as the velocity shift V and the blue-to-red peak intensity ratio of double-peaked profiles for HCN(J ¼ 1 0), CS(J ¼ 2 1), CS(J ¼ 3 2), DCO + (J ¼ 2 1), and N 2 H + (J ¼ 1 0). Four of them, L63, L492, L694-2, and L1197, are found to show a higher blue-to-red ratio in the HCN hyperfine line along the lower opacity, suggesting that infall speed becomes higher toward the center.

The antimicrobial effect of a novel flavonoid (7-O-butylnaringenin) on Helicobacter pylori 26695, 51, and SS1 strains and its inhibitory effect on the urease activity of the strains were evaluated and compared with those of several natural flavonoids. First, various flavonoids were screened for antimicrobial activities using the paper disc diffusion method. Hesperetin and naringenin showed the strongest antimicrobial effects among the natural flavonoids tested, and thus hesperetin and naringenin were selected for comparison with 7-O-butylnaringenin. The antimicrobial effect of 7-O-butylnaringenin was greater than that of the hesperetin and naringenin. H. pylori 51 was more sensitive to 7-O-butylnaringenin (2 log reduction of colony forming units, p < 0.05) than the other two strains at 200 μM. 7-O-Butylnaringenin also showed the highest inhibitory effect against urease activity of H. pylori. Morphological changes of H. pylori 26695 treated with these flavonoids indicated that both hesperetin and 7-O-butylnaringenin at 200 μM damaged the cell membranes.