Purpose To analyze the repeatability of vessel density (VD) measurements and manual foveal avascular zone (FAZ) measurements using optical coherence tomography angiography (OCTA) in patients with retinal vein occlusion (RVO) without macular edema. Methods The study population consisted of patients with RVO and central macular thickness <300 μm. For each subject, measurements were performed twice with a 5-minute interval. The intraclass correlation coefficient (ICC) and coefficient of variation (CV) were calculated to analyze the repeatability of results obtained with the OCTA device. To identify factors related to repeatability, we performed Pearson correlation analyses based on the CV of potential factors. Results A total of 48 eyes were included in the study. The ICCs of the VDs in superficial capillary plexus (SCP) and the deep capillary plexus (DCP) were 0.748 and 0.665, respectively, and the CVs of the VDs in SCP and DCP were 9.1% and 12.6%, respectively. The ICCs associated with the FAZ of the superficial layer (SFAZ) and that of the deep layer (DFAZ) were 0.965 and 0.956, respectively, and the CV of the SFAZ and DFAZ were 8.8% and 9.7%, respectively. From Pearson correlation analyses, OCTA quality was significantly correlated with the CV of the VDs of SCP and DCP. However, there were no variables that were significantly correlated with the CV of SFAZ and DFAZ, including OCTA quality. Conclusions VD measurements in the SCP layer using OCTA exhibited good repeatability, and VD measurements in the DCP layer exhibited relatively low repeatability compared to that of SCP layer measurements in patients with RVO without macular edema after treatment with bevacizumab. Manual measurement of the FAZ area in both SCP and DCP layers resulted in good repeatability. In addition, the repeatability of VD measurements in SCP and DCP layers was correlated with OCTA image quality.

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Purpose:To analyze the clinical presentation, predisposing risk factors, and evaluate the treatment outcomes of Moraxella keratitis. Methods: A retrospective analysis was conducted of 12 culture positive cases of Moraxella keratitis from hospital records between March 2001 and November 2015 at a tertiary hospital to identify and analyze its risk factors, causative microbial organisms, clinical features, and therapeutic outcomes. Results: The mean patient age was 68 years (range, 46-86). The most common cause of keratitis was trauma (six eyes, 50.0%), and half of these patients had diabetes mellitus (three patients, 25.0%). Two patients (16.6%) were previously treated with penetrating keratoplasty. The locations of keratitis involved the central (50.0%) and paracentral (50.0%) regions. Round-shaped corneal infiltration was found in seven eyes (58.3%), and irregular-shaped infiltration was found in five eyes (41.7%). Hypopyon was observed in five eyes (41.7%). All Moraxella isolates were susceptible to aminoglycosides and fluoroquinolones. The isolates from three patients were resistant to trimethoprim/sulfamethoxazole. The mean complete epithelial healing time was 32.4 days. The final visual acuity was 20/1,000 or less in seven eyes (58.3%). Three eyes developed corneal perforations and eventually underwent evisceration. Conclusions: In the Republic of Korea, Moraxella keratitis frequently occurs in eyes with trauma. The treatment response is very slow and has a poor visual outcome; thus, a long period of antibiotic therapy is necessary.

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