Cultivating students' creativity in entrepreneurship education at the college and university level is a key facet of entrepreneurship education in encouraging innovation in students. In this study, the influence of creativity, self-efficacy, entrepreneurial attitude, perceived control, and subjective norms, on students' entrepreneurial intention were examined through a moderated model based on Ajzen's (1985) Theory of Planned Behavior (TPB). A questionnaire survey was used to obtain the data from 523 students from different universities in China's Zhejiang province. SPSS 20.0 was used to conduct descriptive analysis and exploratory analysis of the data, and Amos 22.0 was used to conduct confirmatory factor analysis. The research concluded that creativity has a significant impact on entrepreneurial intention; entrepreneurial self-efficacy has a marked effect on perceived behavior control; and perceived behavioral control, subjective norms and entrepreneurial attitude all significantly affect entrepreneurial intention. Finally, creativity has a significant moderating effect on the roles of perceived behavioral control and subjective norms on entrepreneurial intention, but not on the attitude to entrepreneurship. These results suggest that entrepreneurship education should focus on the cultivation of students' creativity and entrepreneurial efficacy, while encouraging their entrepreneurial intention as well as developing their entrepreneurial skills and mindset.

Phosphodiesterase 4 (PDE4)-dependent cAMP signaling plays a crucial role in cognitive impairment associated with Alzheimer’s disease (AD). However, whether inhibition of PDE4 subtypes or their splice variants in the prefrontal cortex positively regulates synaptic plasticity and antioxidative stress, and reverses β-amyloid 1–42 (Aβ1–42, Aβ42)-induced cognitive impairment still need to be clarified. The present study determined whether and how PDE4D knockdown by microinjection of lenti-PDE4D-miRNA into the prefrontal cortex reversed Aβ1–42-induced cognitive impairment in behavioral, neurochemical, and molecular biology assays. The results suggested that PDE4D knockdown increased time to explore the novel object and decreased latency to leave the platform in novel object recognition and step-down passive avoidance tests. Further study suggested that PDE4D knockdown decreased the number of working memory errors in the eight-arm maze test. These effects were prevented by PKA inhibitor H89. The subsequent experiment suggested that inhibition of PDE4D in the prefrontal cortex rescued the long-term potentiation (LTP) and synaptic proteins’ expression; it also increased antioxidant response by increasing superoxide dismutase (SOD) and decreasing malondialdehyde (MDA) levels. PDE4D knockdown also increased phosphorylated cAMP response element-binding protein (pCREB), brain-derived neurotrophic factor (BNDF), and anti-apoptotic proteins’ expression, i.e., the ratio of Bcl-2/Bax, and decreased caspase-3 level in the prefrontal cortex. These findings extend the previous findings and support the hypothesis that RNA interference-mediated PDE4D knockdown in the prefrontal cortex ameliorated memory loss associated with synaptic failure in an AD mouse model by its antioxidant, anti-apoptotic, and neuroprotective properties.

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