Four prenylflavonoids, bavachin 1, isobavachin 2, 7,4'-dihydroxy-8-prenylflavone 3, and 8-prenylapigenin 4 were synthesized and recognized for possessing estrogen-like activity in MCF-7/BOS cells, as evaluated by an estrogen-screening assay. All compounds significantly stimulated the proliferation of MCF-7/BOS cells in a dose-dependent manner. Isobavachin 2 showed the most potent activity, while bavachin 1 was the weakest. The estrogenic potency of these compounds is ranked as follows: 2 > 4 > 3 > 1.

Synthesis of 4-Aryl-3,4-dihydro-and 2,4-Diaryl-2,3,3a,4-tetrahydrochromeno[3,4-d][1,2,3]diazaphospholes S y n t h e s i s o f 4 -A r y l -3 , 4 -d i h y d r o c h r o m e n o [ 3 , 4 -d ] [ 1 , 2 , 3 ] d i a z a p h o s p h o l e s

Synthesis of 4-Aryl-3,4-dihydro-and 2,4-Diaryl-2,3,3a,4-tetrahydrochromeno[3,4-d][1,2,3]diazaphospholes. -It is demonstrated that a 10:1 mixture of POCl3/SOCl2 is an efficient reagent for the cyclization of carbazones and hydrazones to diazaphosphole derivatives. -(YING, H.; FAN, Y.; LIU, T.; HU*, Y.; Synlett 2007, 16, 2513-2516; Coll. Pharm. Sci., Zhejiang Univ., Hangzhou 310058, Peop. Rep. China; Eng.) -Mais 09-186