No abstract

This work describes a straightforward protocol for the stereoselective synthesis of vinylcyclopropylamides in high E/Z and syn/anti ratios by cyclopropanation of N-tosyl substituted enamides with cyclopropenes in the presence of...

A unique decarbonylation of an amino acid derivative catalytic system has been established via palladium-catalyzed C–C bond and C–N bond dual activations. By employing 8-aminoquinoline as the directing group, this transformation has been found to facilitate the high chemoselectivity to decarbonylation of amino acid derivatives rather than intramolecular deamination or cross-dehydrogenative coupling reactions. This method provides a straightforward avenue for constructing diverse functionalized amide compounds in good to excellent yields. We proposed a possible reaction pathway that may go through the C–C bond and C–N bond dual activations on the basis of the mechanistic studies.