Tinnitus is defined as an unwanted auditory perception of internal origin, usually localized, and rarely heard by others. Persisting appearances of tinnitus are most commonly combined with diseases or damage in the inner ear or neuro-auditory pathway. Diffusion tensor magnetic resonance imaging (DTI) is a new imaging method with the capability of providing non-invasive information on tissue microstructure not available in routine clinical MRI images. Since white matter regions of the brain are an ordered structure due to the myelination and directionality of axons and have a high degree of anisotropy, the ability to detect changes in anisotropy can be extremely useful in the study of diseases such as tinnitus and multiple sclerosis, which are assumed to involve the demyelination of axons. While several studies investigated tinnitus using MRI, few studies tried to analyze neurological disorders quantitatively using DTI. In this study, the cerebral volume of white matter on DTI images of patients with tinnitus was measured using the semi-automated and intuitive menu based image processing tool (Human Analyzer, ETRI, Korea). Total number of ten patients with tinnitus including three women was examined.

Burning mouth syndrome (BMS) is a chronic orofacial pain condition that mainly affects postmenopausal women. BMS type I patients report little to no spontaneous pain in the morning and increases in pain through the day, peaking in the afternoon. Quantitative sensory testing (QST) findings from BMS type 1 patients are inconsistent as they fail to capture this temporal variation. We examined how QST in BMS type 1 compared to healthy participants was affected by time of day. QST of the face and forearm included warmth detection threshold (WDT), cold detection threshold (CDT), and heat pain thresholds (HPT), ratings of suprathreshold heat, and pressure pain thresholds (PPT), and was performed twice: once in the morning and once in the afternoon. BMS patients reported: no differences in morning and afternoon comparisons of the orofacial region between groups and no differences in PPTs in either orofacial or arm regions between groups; lower within group PPTs of the masseter in the afternoon; higher WDTs, and lower CDTs of the forearm in the morning compared to healthy participants; lower CDTs and higher pain intensity ratings to heat stimuli at low temperatures on the forearm in the afternoon compared to healthy participants. The findings indicate that compared to healthy participants, BMS Type I patients had altered thermal sensitivity, which depended on body area tested (forearm vs orofacial region), and higher pain sensitivity, which was slightly more pronounced in the afternoon plausibly due to a hypervigilance.