The scoring system developed using the five independent risk factors had better performance to predict massive transfusion in patients with PPT than when suspicion of placental adhesion was used alone. However, further large-scale studies are warranted to clarify the usefulness and accuracy of this model.

Tidal flats are associated with complicated depositional and ecological environments, and have changed considerably as a result of the erosion and sedimentation caused by tidal energy; consequently, the surface sediment distribution in tidal flats must be constantly monitored and mapped. Although several studies have been conducted with the aim of classifying intertidal surface sediments using various remote sensing methods combined with field survey, most of these studies were unable to consider various sediment types, due to the low spatial resolution of remotely sensed data. Therefore, previous studies were unable to efficiently describe precise surface sediment distribution maps. In the present study, unmanned aerial vehicle (UAV) red, green, blue (RGB) orthoimagery was used in combination with a field survey (232 samples) to produce a large-scale classification map for surface sediment distribution, in accordance with sedimentology standards, using an object-based method. The object-based method is an effective technique that can classify surface sediment distribution by analyzing its correlations with spectral reflectance, grain size, and tidal channels. Therefore, we distinguished six sediment types based on their spectral reflectance and sediment properties, such as grain composition and statistical parameters. The accuracy assessment of the surface sediment classification based on these six types indicated an overall accuracy of 72.8%, with a kappa coefficient of 0.62 and 5-m error range related to the Global Positioning System (GPS) device. We found that 11 samples were misclassified due to the effects of sun glint and cloud caused by the UAV system and shellfish beds, while 14 misclassified samples were influenced by surface water related to the elevation, tidal channels, and sediment properties. These results indicate that large-scale classification of surface sediment with high accuracy is possible using UAV RGB orthoimagery.

Multiple myeloma (MM) is a good target disease in which one can apply cellular immunotherapy, which is based on the graft-versus-myeloma effect. This role of immune effector cells provides the framework for the development of immune-based therapeutic options that use antigen-presenting cells (APCs) with increased potency, such as dendritic cells (DCs), in MM. Current isolated idiotype (Id), myeloma cell lysates, myeloma dying cells, DC-myeloma hybrids, or DC transfected with tumor-derived RNA has been used for immunotherapy with DCs. Immunological inhibitory cytokines, such as TGF-β, IL-10, IL-6 and VEGF, which are produced from myeloma cells, can modulate antitumor host immune response, including the abrogation of DC function, by constitutive activation of STAT3. Therefore, even the immune responses have been observed in clinical trials, the clinical response was rarely improved following DC vaccinations in MM patients. We are going to discuss how to improve the efficacy of DC vaccination in MM.

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