ABSTRACT. Sparing effects of carprofen and meloxicam with or without butorphanol on the minimum alveolar concentration (MAC) of sevoflurane were determined in 6 dogs. Anesthesia was induced and maintained with sevoflurane in oxygen, and MAC was determined by use of a tail clamp method. The dogs were administered a subcutaneous injection of carprofen (4 mg/kg) or meloxicam (0.2 mg/kg), or no medication (control) one hour prior to induction of anesthesia. Following the initial determination of MAC, butorphanol (0.3 mg/ kg) was administered intramuscularly, and MAC was determined again. The sevoflurane MACs for carprofen alone (2.10 ± 0.26%) and meloxicam alone (2.06 ± 0.20%) were significantly less than the control (2.39 ± 0.26%). The sevoflurane MACs for the combination of carprofen with butorphanol (1.78 ± 0.20%) and meloxicam with butorphanol (1.66 ± 0.29%) were also significantly less than the control value after the administration of butorphanol (2.12 ± 0.28%). The sevoflurane sparing effects of the combinations of carprofen with butorphanol and meloxicam with butorphanol were additive.

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A total of 383 cases with cancer recieved surgical management from 1973 to 1986. Of them, there were 179 cases of gastric cancer (46.7%), 66 cases of colon cancer (15.7%), 45 cases of rectal cancer (11.7%), 31 cases of breast cancer (8.1%) and 19 cases of pancreatic cancer (5.0%).According to Warren and Gates' criteria, there were 20 cases of double cancer (5.2%). Most (95%) cases of double cancer were combined with digestive tract cancer, 55% with gastric cancer, 5 cases with double gastric cancer, 3 with rectal cancer and 3 with other cancers.The average age of patients was 64.3 years (36-86 years) and the male/female ratio was about 1.5. Four-fifths of the 40 pathological lesions were adenocarcinoma.

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