Isetexane diterpene analogues were semisynthesized from demethylsalvicanol isolated from Perovskia abrotanoides (Labiatae). The structure and cytotoxic activity relationships (SAR) of the natural parent diterpene, demethylsalvicanol, and its semisynthetic analogues were studied by using P388 murine leukemia cells.
S(R)()-Podolactone D (1), a new norditerpene dilactone having a methylsulfoxide moiety, was isolated from the leaves of Podocarpus macrophyllus D. Don var. maki Endl. along with known podolactone D (2, S(S)()-podolactone D). The structures and absolute configurations of compounds 1 and 2 were elucidated by spectral methods (HREIMS, IR, (1)H, (13)C, and 2D NMR) and finally confirmed by single-crystal X-ray analyses. The cytotoxic effects of compounds 1 and 2 on P388 murine leukemia cells were also examined.
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