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Charcot-Marie-Tooth disease (CMT) is an inherited heterogeneous group of peripheral nerve disorders with characterized by weakness and sensory loss in the distal limbs. General anesthesia was induced with propofol, rocuronium, and remifentanil. At the end of the surgery, we administered a total of 150 mg sugammadex. The patient could lift his head and arms, open his eyes. Then we extubated tracheal tube. We successfully used sugammadex in a patient with CMT to reverse rocuronium-induced neuromuscular blockade. However, muscle relaxation might not be measured accurately in CMT patients. Thus, clinical findings should be referred to in the management of anesthesia.

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Permanent proliferation and cornification of the vaginal epithelium occurred in adult ovariectomized (OVX) mice which had received neonatal injections of 5 micrograms diethylstilbestrol (DES). Occurrence of the permanent epithelial proliferation was prevented by injections of 200 IU vitamin A acetate (VA) given simultaneously with neonatal DES-treatment in mice when OVX at 30 days of age, but not in those OVX at 270 days. For the suppression of the permanent vaginal changes, however, more than one month were required after DES plus VA-treatment. In DES plus VA-treated OVX (at 30 days) mice, the vaginal epithelium indicated a lower mitotic rate than in DES-treated OVX mice. Clear cells were found in the degenerating vaginal epithelium in 63% of DES plus VA-treated OVX mice, while in the proliferated epithelium, this type of cells appeared only in 10% of DES-treated OVX mice. In 40% of 180-day-old, DES-treated OVX (at 30 days) mice, permanent stratification took place in the uterine epithelium, while it was inhibited in the age-matched DES plus VA-treated OVX mice. However, the uterine change was not prevented in 310-day-old, DES plus VA-treated mice when OVX at 270 days. This findings suggests that the relatively long-term presence of ovaries nullifys the inhibitory effect by VA on the occurrence of permanent changes in the utero-vaginal epithelium induced by neonatal DES treatment.