These data demonstrated that both PDGF-AB and TGF-beta1 were highly concentrated in the PRP preparations. It is suggested PRP modulates cell proliferation in a cell type-specific manner similar to what has been observed with TGF-beta1. Since synchronized behavior of related cell types is thought to be required for successful periodontal regeneration, it is further suggested these cell type-specific actions may be beneficial for periodontal regenerative therapy.

Treatment with a combination of PRP and HA compared to HA with saline led to a significantly more favorable clinical improvement in intrabony periodontal defects.

SummaryA cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2

The Telescope Array (TA) observatory utilizes fluorescence detectors and surface detectors (SDs) to observe air showers produced by ultra high energy cosmic rays in Earth’s atmosphere. Cosmic-ray events observed in this way are termed hybrid data. The depth of air shower maximum is related to the mass of the primary particle that generates the shower. This paper reports on shower maxima data collected over 8.5 yr using the Black Rock Mesa and Long Ridge fluorescence detectors in conjunction with the array of SDs. We compare the means and standard deviations of the observed X max distributions with Monte Carlo X max distributions of unmixed protons, helium, nitrogen, and iron, all generated using the QGSJet II-04 hadronic model. We also perform an unbinned maximum likelihood test of the observed data, which is subjected to variable systematic shifting of the data X max distributions to allow us to test the full distributions, and compare them to the Monte Carlo to see which elements are not compatible with the observed data. For all energy bins, QGSJet II-04 protons are found to be compatible with TA hybrid data at the 95% confidence level after some systematic X max shifting of the data. Three other QGSJet II-04 elements are found to be compatible using the same test procedure in an energy range limited to the highest energies where data statistics are sparse.

We report on a measurement of the cosmic ray composition by the Telescope Array Low-Energy Extension (TALE) air fluorescence detector (FD). By making use of the Cherenkov light signal in addition to air fluorescence light from cosmic ray (CR) induced extensive air showers, the TALE FD can measure the properties of the cosmic rays with energies as low as ∼ 2 PeV and exceeding 1 EeV. In this paper, we present results on the measurement of X max distributions of showers observed over this energy range. Data collected over a period of ∼ 4 years was analyzed for this study. The resulting X max distributions are compared to the Monte Carlo (MC) simulated data distributions for primary cosmic rays with varying composition and a 4-component fit is performed. The comparison and fit are performed for energy bins, of width 0.1 or 0.2 in log 10 (E/eV), spanning the full range of the measured energies. We also examine the mean X max value as a function of energy for cosmic rays with energies greater than 10 15.8 eV. Below 10 17.3 eV, the slope of the mean X max as a function of energy (the elongation rate) for the data is significantly smaller than that of all elements in the models, indicating that the composition is becoming heavier with energy in this energy range. This is consistent with a rigidity-dependent cutoff of events from galactic sources. Finally, an increase in the X max elongation rate is observed at energies just above 10 17 eV indicating another change in the cosmic rays composition.