Abstract:Osteoporosis is a growing chronic health problem that could result in mortalities and poor living quality.Although osteoporosis is a preventable disease affecting millions of people, the public awareness remains low and the most effective prevention of this disease is founded during childhood and adolescence when the prevention is actually the easiest. Aim: The current study assessed osteoporosis knowledge among female adolescents students in selected secondary school at El-Minia, Egypt. Methods: Information was gathered through across-sectional survey. Self-administered questionnaire consisted of 58 items assessing knowledge regarding osteoporosis was administered to one hundred and twelve female adolescent aged 15-18 years in one secondary school. Descriptive statistics was used to analyze the data. Results: Regarding knowledge of the studied sample about osteoporosis, it was found that 38.4 % of the studied sample didn't know the meaning of osteoporosis, more over 75.9 % of them didn't know what to do in the case of osteoporosis. Majority of the studied sample (90.2 %) mentioned exposure to sunlight as one of the preventive measures from osteoporosis. Conclusion: The present study revealed lack of awareness about osteoporosis among female adolescent, hence the findings highlight the need for educational interventions to enhance female adolescents' knowledge about osteoporosis.