Aims After the COVID-19 pandemic, the risk of thrombosis and bleeding has been an important issue. It is reported that higher D-dimer levels are associated with poor prognosis. Cardiovascular disease risk has also been reported to poor prognosis of COVID-19. Both cardiovascular disease risk and high D-dimer level can be a lethal combination leading to death in COVID-19 patients. We are aiming this research to analyse the capability ten-year risk of fatal cardiovascular disease obtained from SCORE-Risk chart to predict the D-dimer level in hospitalised COVID-19 patients. Methods and Results This is a cross-sectional study including 85 moderate-severe hospitalised COVID-19 patients without previous cardiovascular disease. We assessed the patient’s cardiovascular risk by using SCORE-Risk chart and separate samples into two D-dimer groups. Comparison between patient’s clinical variables and D-Dimer level is done by using Mann-Whitney analysis. Variables which show p value <0.2 will then be analysed by Logistic Regression. There are 27 patients (31.8%) with a high cardiovascular risk. Median D-dimer is 560 ng/mL. Mann-Whitney analysis comparing patient’s clinical variables with D-dimer shows CRP, blood glucose, lactic acid and SCORE-Risk chart give p-value with value < 0.2. The logistic regression analysis shows that SCORE-Risk chart is the strongest predictor of higher D-dimer level with OR 5.647 (1.670-19.092; p value 0.005) with 88.2% specificity and 45.1% sensitivity. Conclusions Ten-year risk of fatal cardiovascular disease measured by SCORE-risk chart can be used as accurate predictor of higher D-dimer level on moderate-severe COVID-19 patients.