Inflammatory bowel disease (IBD) is a chronic recurrent intestinal disease and includes Crohn's disease (CD) and ulcerative colitis (UC). Due to the complex etiology of colitis, the current treatments of IBD are quite limited and are mainly concentrated on the remission of the disease. In addition, the side effects of conventional drugs on the body cannot be ignored. IBD also has a certain relationship with colitis-associated cancer (CAC), and inflammatory cells can produce a large number of tumor-promoting cytokines to promote tumor progression. In recent years, exosomes from plants have been found to have the ability to load drugs to target the intestine and have great potential for the treatment of intestinal diseases. This plant-derived exosome-targeting delivery system can load chemical or nucleic acid drugs and deliver them to intestinal inflammatory sites stably and efficiently. This review summarizes the pathophysiological characteristics of IBD and CAC as well as the application and prospect of plant exosomes in the treatment of IBD and CAC.
Aluminum‐ion batteries (Al‐ion batteries) have become a potential energy storage system, owing to their excellent cycling performance, three‐electron‐redox properties, and safety performance. Until now, great progress has been made in Al‐ion batteries. However, the Al‐ion battery system still encounters various problems, such as high electrolyte price, harsh working environment, low discharge platforms, and inferior capacity. Here, we prepared a novel Al‐ion battery with AlCl3/Imidazole hydrochloride (ImidazoleHCl) as the electrolyte, aluminum as the negative electrode, and commercial graphite as the positive electrode. The battery achieves a high specific discharge capacity of 129 mA h g−1 at a current density of 0.5 A g−1 and 105 mA h g−1 with a high coulombic efficiency of 99 % at the current density of 4 A g−1 after 1000 cycles. The mechanism of AlCl4− intercalation/de‐intercalation is proved by Raman, XRD and EDS studies. ImidazoleHCl is a promising electrolyte and this work provides a new insight for the Al‐ion battery system.
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