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trial achieved positive results of reduced itch intensity and other supporting efficacy endpoints in prurigo nodularis patients New Haven, CT, October 13, 2016 -Trevi Therapeutics, Inc. ("Trevi" or the "Company"), a late-stage clinical development company developing oral Nalbuphine ® ER for chronic pruritus conditions, today announced positive results from its Phase 2 trial for the treatment of moderate to severe prurigo nodularis. Prurigo nodularis (PN), a severely pruritic dermatological condition characterized by itchy skin papules and nodules, has significant impact on quality of life and has no approved therapies. Trevi also previously reported statistically significant results from a robust Phase 2/3 trial with Nalbuphine ER in hemodialysis patients with uremic pruritus.

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