A tandem acetylene-activated
SNAr-anionic cyclization
strategy is presented for the synthesis of chalcogen-containing hetero[5]helicenes.
Oxa-, thia-, and selena[5]helicenes are accessed from common ortho-fluoro-ethynylarene precursors, allowing the heteroatoms
to be installed at the 1-position or 1- and 12-positions of the hetero[5]helicene
inner core surface.
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