Phenyltetrazole substituted compounds, namely 5-phenyl-1H-tetrazole (PT), 5-(4chlorophenyl)-1H-tetrazole (Cl-PT), 5-(4-methoxyphenyl)-1H-tetrazole (MO-PT) and 5-p-tolyl-1H-tetrazole (M-PT) were synthesized to study their inhibition behavior on mild steel in 1 M HCl by weight loss measurement, potentiodynamic polarization studies and electrochemical impedance spectroscopy (EIS). It has been observed that corrosion rate decreases and inhibition efficiency increases with increasing in phenyltetrazole substituted concentration and dependence on molecular structure. Polarization data indicate that these compounds act as very good cathodic inhibitors of mild steel in 1 M HCl. The result showed that the inhibition efficiency decreased with temperature and increased with immersion time. EIS has the same trend of inhibitive effect as that of the polarization data, which indicates the formation of a protective layer on mild steel surface by molecules adsorption.

The compound, diethyl 1-((4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl)-1H-1,2,3-triazole-4,5-dicarboxylate 2, was synthesized in high yield, through 1,3-dipolar cycloaddition reaction of 4-(azidomethyl)-4-methyl-2-phenyl-4,5-dihydrooxazole and diethyl but-2-ynedioate in the absence of a solvent. The structure of the synthesized compound was established on the basis of NMR spectroscopy ( 1 H, 13 C), X-ray crystallography, and MS data. The prepared compound was also tested in vitro for its antibacterial activity against Gram-positive bacteria (Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli). The calculation of MBC/MIC ratio showed that this triazole derivative 2 had a bactericidal effect on the two strains tested.

The N-alkylation reaction of N-benzoyl 5-(aminomethyl)tetrazole (5-AMT) with benzyl bromide was carried out in the presence of K2CO3 as a base. Two separable regioisomers were obtained, thus their purification led to determine the proportion of each of them, and their structures were attributed essentially based on 1H and 13C NMR spectroscopy in addition to the elemental analysis and MS data. In order to confirm the results obtained at the synthesis level, a computational study was carried out by application of density functional theory (DFT) using the Becke three-parameter hybrid exchange functional and the Lee-Yang-Parr correlation functional (B3LYP).

The title compound, N,methyl)]- 1H-1,2,3-triazol-4-yl) Continuing our investigations in the use of oxazoline derivatives [6][7][8] in heterocyclic synthesis, we present in this short note a convenient and easy procedure for the preparation of N, N-dibenzyl-1-(1-[(4-methyl-2-phenyl-4,5-dihydrooxazol-4-yl)methyl)]-1H-1,2,3-triazol-4-yl)methanamine 3, a new oxazolinic precursors of heterocyclic amino acids.For the first time, we prepared the terminal alkyne N,N-dibenzylprop-2-yn-1-amine 2 by the reaction of N-alkyaltion of propargyl bromide by dibenzylamine in anhydrous acetone at room temperature in the presence of K 2 CO 3 as base [9]. The intermediate 2 is obtained with a 92% yield as colorless oil, and then it was submitted to cycloaddition reaction with azide 1. OPEN ACCESS

A simple synthetic approach to racemic N-tert-butyloxycarbonyl-2-methyl-3-(1H-1,2,4-triazol-1-yl)alanine (5) in four steps and 68% overall yield starting from oxazoline derivative 1 is reported. This synthesis involves the alkylation of 1H-1,2,4-triazole with an O-tosyloxazoline derivative, followed by an oxazoline ring-opening reaction and oxidation of the N-protected β‑aminoalcohol by potassium permanganate.