: The COVID-19 caused by a new type of coronavirus has emerged from China and led to thousands of deaths globally. Despite many groups engaged in studying the newly emerged virus and searching for the treatment, the understanding of the SARS-CoV2 target ligand interactions represents a key challenge. Several studies are being conducted to identify potential treatment. Alternatively, the results of numerous studies have shown that protease inhibitors can be a genuine leader in research. The antiviral activity and beneficial effect against respiratory disorders of thymoquinone have been largely demonstrated. The aim of this study is to testing In Silico the inhibition of the replication of SARS CoV2 by thymoquinone. This is a molecular simulation study using SARS CoV2 protease and thymoquinone structures provided by Protein Data Bank. The preliminary results have shown that thymoquinone may have inhibitory activities against SARS CoV2 protease. Furthermore, given the demonstrated results of thymoquinone, we can conclude that it may be considered as an effective or adjuvant treatment for SARS CoV2 infection.

Background: Depression is a group of syndromes characterized by notable and persistent mood disorders, and is one of the most prevalent psychiatric disorders, while the existing treatments have an altered risk-benefit balance. The therapeutic properties of Nigella have been confirmed, suggesting the reliance on phytotherapy. The objective of the present paper is to investigate the antidepressive-like effect of Nigella sativa on rats exposed to the Unpredictable Chronic Mild Stress procedure. Methods: Wistar rats were used to investigate the antidepressive-like effect. The stress procedure used in this study combined many stressful conditions. After 6 weeks of treatment, behavioral test (forced swim test) was conducted, and histological changes of the hippocampus were examined. Results: Treatment by nigella and fluoxetine significantly reduced the struggling time. Conclusion: Histopathological analysis showed that control treatments result in more loosely arranged cells, significant apoptotic neurons characterized by an irregular appearance, and pyknotic hyperchromatic. A reduction of the thickness of the pyramid layer was also observed in the groups treated with nigella and fluoxetine, suggesting that nigella could be used as a treatment or an adjuvant preventing depressive-like disorders.

The COVID-19 caused by a new type of coronavirus has emerged from China and led to thousands of death globally. Despite the efforts engaged in studying this newly emerged virus and searching for its treatment, the understanding of the COVID-19 drug and target protein interactions still represent a key challenge. At present, there is no medical treatment that has been persuasively demonstrated to improve results in patients affected by SARS-CoV2. Several molecules have demonstrated In-Vitro activity against the SARS-CoV-2 virus and/or potential clinical benefit in observational and non-randomized studies. Randomized clinical trials of an appropriate size are currently ongoing to establish the efficacy of these therapeutic proposals. Herein, concerning these diverse guidelines and therapeutic suggestions of different approaches to the treatment, this research aims to provide a molecular analysis of the interaction between the principal molecules cited in bibliography and the active protease site of the virus.

Due to the confirmation of the therapeutic properties of oils extracted from Nigella, and the constraints associated with antidepressant prescriptions, the reliance on phototherapy seems to be beneficial. The objective of the present paper is to investigate the behavioral effect of Nigella fixed oil, as well as exploring the histopathological impact on the structure of the hippocampus after exposure to the Unpredictable Chronic Mild Stress procedure in rats. Animals were randomly divided into five groups of eight. The stress procedure used in this study combines many stressful situations. These situations were randomly assigned with a frequency of two stressors per day throughout the 5‐weeks. Behavioral evaluation of antidepressant activity was based on the forced swimming test and histological evaluation of the hippocampus of rats with optical microscopy. Treatment by nigella and fluoxetine significantly reduces the struggling time during the test day of the forced swim test. Histopathological analysis showed that control treatments result in more loosely arranged cells, significant apoptotic neurons characterized by an irregular appearance, and pyknotic hyperchromatic. As well as a reduction in the thickness of the pyramid layer compared to the groups treated with nigella and fluoxetine. The results demonstrated the effect of Nigella in the forced swimming test, as well as the improvement of the pyramidal cell organization and neuronal degeneration. These data seem to be consistent with other studies, in which the neuroprotective properties of nigella refer to thymoquinone.

Background: Many researches papers have demonstrated that Nigella has neurotropic properties, and it has also been shown that Nigella seeds have several activities, such as analgesic, antiepileptic, anxiolytic, antidepressant, and psychostimulant activities. Methods: Databases such as PubMed, Science Direct, Scopus, and Google Scholar were used. Results : The orientation towards this type of research has become more and more accentuated to enhance and detail the pharmacological properties of medicinal aromatic plants. Conclusion : The present review consists in revealing and combining the experimental research studies carried out to demonstrate the central effects of nigella.