Introduction Transurethral resection of the prostate (TURP) is considered the gold standard surgical treatment for lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia. The number of TURPs performed has declined significantly over the last three decades owing to pharmaceutical therapy. TURP data from a single institution for the years 1990, 2000 and 2010 were compared to assess the difference in performance. Methods A retrospective analysis was undertaken of all patients who underwent TURP between January and December 2010. These findings were compared with historical data for the years 1990 and 2000: 100 sets of case notes were selected randomly from each of these years. Results The number of TURPs performed fell from 326 in 1990 to 113 in 2010. The mean age of patients increased from 70.6 years to 74.0 years. There was also a significant increase in the mean ASA grade from 1.9 to 2.3. The most common indication for TURP shifted from LUTS to acute urinary retention. No significant change in operating time was observed. The mean resection weight remained constant (22.95g in 1990, 22.55g in 2000, 20.76g in 2010). A reduction in transfusion rates was observed but there were higher rates of secondary haematuria and bladder neck stenosis. There was an increase from 2% to 11.5% of patients with long-term failure to void following TURP. Conclusions The number of TURPs performed continues to decline, which could lead to potential training issues. Urinary retention is still by far the most common indication. However, there has been a significant rise in the percentage of men presenting for TURP with high pressure chronic retention. The number of patients with bladder dysfunction who either have persistent storage LUTS or eventually require long-term catheterisation or intermittent self-catheterisation has increased markedly, which raises the question of what the long-term real life impact of medical therapy is on men with LUTS secondary to benign prostatic hyperplasia who eventually require surgery.

<div>Atomic layer deposition (ALD) of LiF and lithium ion conducting (AlF₃)(LiF)_x alloys was developed using trimethylaluminum, lithium hexamethyldisilazide (LiHMDS) and hydrogen fluoride derived from HF-pyridine solution. ALD of LiF was studied using in situ quartz crystal microbalance (QCM) and in situ quadrupole mass spectrometer (QMS) at reaction temperatures between 125°C and 250°C. A mass gain per cycle of 12 ng/(cm² cycle) was obtained from QCM measurements at 150°C and decreased at higher temperatures. QMS detected FSi(CH₃)₃ as a reaction byproduct instead of HMDS at 150°C. LiF ALD showed self-limiting behavior. Ex situ measurements using X-ray reflectivity (XRR) and spectroscopic ellipsometry (SE) showed a growth rate of 0.5-0.6 Å/cycle, in good agreement with the in situ QCM measurements.</div><div>ALD of lithium ion conducting (AlF3)(LiF)x alloys was also demonstrated using in situ QCM and in situ QMS at reaction temperatures at 150°C A mass gain per sequence of 22 ng/(cm² cycle) was obtained from QCM measurements at 150°C. Ex situ measurements using XRR and SE showed a linear growth rate of 0.9 Å/sequence, in good agreement with the in situ QCM measurements. Stoichiometry between AlF₃ and LiF by QCM experiment was calculated to 1:2.8. XPS showed LiF film consist of lithium and fluorine. XPS also showed (AlF₃)(LiF)x alloy consists of aluminum, lithium and fluorine. Carbon, oxygen, and nitrogen impurities were both below the detection limit of XPS. Grazing incidence X-ray diffraction (GIXRD) observed that LiF and (AlF₃)(LiF)_x alloy film have crystalline structures. Inductively coupled plasma mass spectrometry (ICP-MS) and ionic chromatography revealed atomic ratio of Li:F=1:1.1 and Al:Li:F=1:2.7: 5.4 for (AlF₃)(LiF)_x alloy film. These atomic ratios were consistent with the calculation from QCM experiments. Finally, lithium ion conductivity (AlF₃)(LiF)_x alloy film was measured as σ = 7.5 × 10^-6 S/cm.</div>

Thirty cull Scottish Blackface ewes were scanned three times over a period of 1 week using X-ray computed tomography (CT). Cross-sectional CT reference scans were taken at seven anatomical sites per ewe: ischium (ISC), femur (FEM), hip (HIP), 5th lumbar vertebra (LV5), 2nd lumbar vertebra (LV2), 8th thoracic vertebra (TV8) and 6th thoracic vertebra (TV6). Ewes were then slaughtered and dissection measurements collected.Results of multiple regression analyses suggested that five reference scans allow accurate prediction of total weights of bone, muscle and fat (carcass and internal). The most informative cross-sectional scans were ISC, HIP, LV5, LV2 and TV8, from which prediction equations were derived. Fat and muscle weights were predicted accurately (R2= 80 to 99%) but bone weight was predicted less accurately (R2= 56%). Repeatabilities were high for the CT measurements used to predict fat and muscle (0•82 to 0•99) but lower for those used to predict bone (0•19 to 0• 86).

Tissue depletion and repletion were investigated in 142 Scottish Blackface ewes using computed tomography (CT). Ewes of two ages (2 or 3 years) and differing reproductive status (barren, single- or twin-bearing) were studied through one annual production cycle to investigate mobilization of carcass fat (subcutaneous and inter-muscular), internal fat and muscle.Ewes were CT scanned five times during the 1-year study period: pre-mating; pre-lambing; mid-lactation; weaning; pre-mating the following year. For each animal at each of the five scanning events cross-sectional CT scans were taken at five anatomical sites (ischium, hip, 5th lumbar vertebra, 2nd lumbar vertebra and 8th thoracic vertebra). CT images were analysed to yield areas of carcass fat, muscle and internal fat and total weights of these tissues were estimated at each scanning event using prediction equations derived from a separate calibration data set.The results show that both carcass and internal fat depots were depleted during pregnancy and early lactation and repleted from mid-lactation to mating the following year. In proportionate terms, internal fat was most labile, but carcass fat contributed more to total weight change because it was a bigger fat depot. Subcutaneous fat was the largest and most labile of the carcass fat depots. Muscle reserves were depleted only when fat reserves had fallen to very low levels. Older ewes carried more carcass fat in total than younger ewes when reserves were low. Mobilization of tissue reserves in twin-bearing ewes was less than in single-bearing ewes, probably due to preferential feeding.

Hill ewes undergo large changes in body fat and muscle weight throughout the annual production cycle as they contend with the pressures of reproduction and lactation, as well as harsh environmental conditions. This study modelled seasonal changes in fat and muscle weights in Scottish Blackface hill ewes throughout their productive lifetime using random regression statistical techniques.Scottish Blackface ewes (no. = 308) were scanned using computed tomography (CT) four times per year, from 2 until 5 years old. Heritabilities of tissue weights were estimated at 2-weekly intervals throughout the productive life of the ewe. Genetic correlations between tissue weights at the same point in the production cycle at different ages, and between tissue weights at different events within each annual production cycle were predicted. Animal solutions from random regression analyses were used to estimate tissue weights, from pre-mating at 2 years old to weaning at 5 years old. The effects of litter size in the current and previous production years on fat and muscle weights were investigated.Correlations between CT tissue weights and those predicted by a sin/cos random regression model were 0.87, 0.84, 0.88 for carcass fat, internal fat and muscle respectively. Heritabilities ranged from 0.31 to 0.90 for carcass fat weight, 0.21 to 0.68 for internal fat weight and 0.26 to 0.57 for muscle weight, throughout the productive lifetime of the ewe. Heritabilities were highest during mating for fat weights, and during the dry period and lambing time for muscle weights. Heritabilities of tissue weights in 3-year-old ewes were higher than in other age groups. Genetic correlations were 1.00 between tissue weights at the same scanning event at different ages, but ranged from close to zero to 0.97 between scanning events within age groups. Clearly environmental variation across time was large. The number of lambs produced in both the current and the previous year influenced tissue levels. Ewes that did not produce lambs (barren) in a given year carried more muscle during that year than ewes producing lambs. As ewes aged, barren ewes carried increasingly more carcass fat and muscle than ewes with lambs. Barren ewes also had significantly more muscle during the following year than ewes that had weaned lambs. Ewes that reared twins had significantly less carcass fat the following year than singleton-bearing or barren ewes. These effects of previous litter size increased significantly with age.