Various 3-haloflavones were prepared by the reaction of the corresponding flavone derivatives with iodobenzene diacetate and trimethylsilyl halide under mild reaction conditions. The iodobenzene diacetate could be replaced by the polymersupported iodobenzene diacetate without the decreasing activity.The synthesis of a-haloenones from a,b-unsaturated carbonyl compounds provides an important functional group that facilitates palladium catalyzed carbon-carbon bond formation. 2 The application of this type of methodology to flavone has been rare despite the widespread synthetic utility of bisflavonoid intermediate. Therefore, new methods for the convenient 2101

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Various 3-halo flavones were prepared by reaction of the corresponding flavone derivatives with R 4 NBr/PhI(OAc) 2 system under mild reaction conditions. Halogenated compounds are important intermediates for converting efficiently into other functionality by simple chemical transformations.

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