<b><i>Background:</i></b> Dry eye disease (DED) is the most common ocular surface disease, which severely affects the quality of life. An overall estimate of the prevalence, incidence, and risk factors of DED in Asia would help in planning and implementing appropriate public health strategies. <b><i>Objectives:</i></b> The present study aimed to study the epidemiology of DED in Asia. <b><i>Methods:</i></b> A comprehensive and systematic search was performed using several databases, including PubMed, Cochrane Library, and Web of Science, in January 2021. A random-effects meta-analysis was performed on logit-transformed prevalence and incidence rates to calculate pooled prevalence and incidence estimates. Meta-regression and subgroup analyses were performed to explain the heterogeneity. <b><i>Results:</i></b> Among the 6,742 articles identified, 23 were included in the analysis, with a total sample size of 1,488,935 subjects. Twenty studies reported the prevalence of DED in Asia, two studies reported the incidence, and one study reported both prevalence and incidence. The estimated pooled prevalence of DED in any population in Asia was 20.1% (95% confidence interval [Ozdemir et al., Acta Ophthalmol. 2019;97(1):e91–6]: 13.9–28.3%), and the incidence 16.7% (95% CI: 0–34.9%). The prevalence rate of DED in males and females was 16.4% (95% CI: 10.0–25.8%) and 21.7% (95% CI: 14.7–30.8%; <i>p</i> &#x3c; 0.001), respectively. In general, the prevalence increased with age. The risk factors considered for specific populations were not significant, and the prevalence in the general population, excluding the populations considered at risk, was similar at 20.9% (95% CI: 12.8–32.1%). <b><i>Conclusions:</i></b> DED is common in Asian populations and causes a significant disease burden. Its prevalence is higher in females than that in males, and it tends to increase in severity with age. Further research on additional risk factors is needed to adequately explain the epidemiology of DED in Asia.

PurposeTo provide preliminary data on the efficacy and safety of oral voriconazole (VCZ) as a primary treatment for fungal keratitis (FK).MethodWe performed a retrospective histopathological analysis of data on 90 patients with FK at The First Affiliated Hospital of Guangxi Medical University between September 2018 and February 2022. We recorded three outcomes: corneal epithelial healing, visual acuity (VA) improvement, and corneal perforation. Independent predictors were identified using univariate analysis, and multivariate logistic regression analysis was used to identify independent predictive factors associated with the three outcomes. The area under the curve was used to evaluate the predictive value of these factors.ResultsNinety patients were treated with VCZ tablets as the only antifungal drug. Overall, 71.1% (n = 64) of the patients had extreme corneal epithelial healing, 56.7% (n = 51) showed an improvement in VA, and 14.4% (n = 13) developed perforation during treatment. Non-cured patients were more likely to have large ulcers (≥5 × 5 mm2) and hypopyon.ConclusionThe results indicated that oral VCZ monotherapy was successful in the patients with FK in our study. Patients with ulcers larger than 5 × 5 mm2 and hypopyon were less likely to respond to this treatment.

Background: A lot of research have been focused on the area of the arti cial cornea, in our study, a bibliometric analysis was performed on the arti cial cornea to identify the global key research elds and trends over the past 20 years.Methods: Publications about arti cial cornea were retrieved and downloaded from the Web of Science Core Collection (WoSCC) from 2002 to 2021. Citespace and VOSviewer were used to analyze countries, institutions, authors, and related research areas.Results: A total of 829 eligible publications were analyzed. The USA was the most productive country for arti cial cornea, followed by China and Canada. Harvard University was the most proli c institution in this eld. Cornea published most of the studies in this area and Dohlman CH was the most cited author.Conclusions: Bibliometric analysis in our study rstly provides a general perspective on the arti cial cornea, which can be helpful to further explore the issues in the rapidly developing area.