From the last decade flavonoids have become very prominent in the studies related to grapes. It has also been outlined by the recent researches that the positive effects of the constituents derived from theresidues of grapes are due to the polyphenolic compounds. Grape Seed Extract (GSE) possess a wide spectrum of medicinal features to inhibit reaction of free radicals, prevent clumping of platelets, prevent inflammation etc. Apart from that GSE have gastro-protective, hepato-protective, and cardio-protective roles. It has been reveal that the residues derived from the seeds of the grapes with enhanced flavonol constituents are important to be utilized during the conditions of fungal infections as vaginal candidiasis due to candida preventing c h a r a c t e risti c s. Du e t o t h e p r e s e n c e o f proanthocyanidins grape seeds are used as a food supplement also.