In order to draw a trajectory of use and utility of the conventional technique such as ozone therapy going through its historical trajectory and its effectiveness, mainly with regard to the treatment of painful and chronic inflammatory processes. The technique called “ozone therapy” is recommended for the use of ozone gas (5%) and oxygen (95%), being used to treat injuries, especially wounds and having been described in scientific articles as an alternative to suffering pain, inflammation, infection and wound healing. Scientific publications evidence or benefit ozone, it as an important option in the treatment or association of treatment of patients with chronic diseases. Such as example in the other techniques under supervision and validation, there are recommendations from new studies that establish the safety of the use of ozone in health and aesthetic procedures. Therefore, this study aims to present a literature review that includes relevant information on the ozone therapy technique, investing in information about the processes and methods used in various diseases, and especially in the treatment of chronic painful and inflammation. After applying the article selection, selecting 39 articles published in the years 2019 and 2020, describing the use of ozone therapy to treat pain and inflammation in various pathologies. The results that ozone therapy is presented as a therapeutic option, minimally invasive and inexpensive, can be used in conjunction with other therapeutic measures to enhance the beneficial results of resources and can be integrated into Alternative and Complementary Practices.