Changes in the amplitude and dynamic parameters of purposive saccades were studied in monkeys with MPTP-induced Parkinson-like syndrome. Lengthening of saccade latency, decreased maximum velocity of eye movements, and impaired saccade accuracy were observed at the early stages MPTP-syndrome. Different disturbances of large- and small-scale saccades were found.

The effects of Semax heptapeptide on the resistance to acute hypobaric hypoxia and on hypoxic changes in the ECG chronotropic index were studied in 14-and 21-day-old pups. The resistance to hypoxia decreased with age. Hypoxic exposure caused bradycardia in both age groups. Semax reduced the bradycardiac reaction and exerted an antiarrhythmic effect without affecting the resistance to hypoxia.Key Words: acute hypobaric hypoxia; neonates; Semax; ECG Hypobaric hypoxia as an extreme condition has attracted considerable attention because of its great significance for clinical practice. Of special interest are hypoxic conditions in children during the antenatal and early postnatal periods.Hypoxia causes a variety of symptoms, in particular, changes in the cardiovascular system, depletion of myocardial energy resources, impairment of circulation, hypotension, venous hypertension, and cerebral ischemia. The severity of cardiovascular disorders directly correlates with the duration of intrauterine hypoxia. In infants with severe asphyxia, the ECG recorded during the first postnatal days displays bradycardia with impaired intraatrial, atrioventricular, and intraventricular conductivity [3].In this connection, it is of considerable interest to study hypoxic changes in a cardiac chronotropic index during the early postnatal period in animals.Recently, the antihypoxic effects of the heptapeptide ACTH4_v-Pro-Gly-Pro (Semax) have been intensely investigated [4], however its efficiency in the early postnatal period has not yet been studied. MATERIALS AND METHODSThe study was carried out on 91 pups (males and females) of outbred albino rats exposed to acute hypobaric hypoxia on the 14th and 21st days of life.Acute hypobaric hypoxia was modeled in a pressure chamber by "lifting" to an "altitude" of 11,500 m above sea level for 1 min.During hypoxic exposure the following indices were recorded: the time of posture loss (PLT), the time of survival (ST), i.e., the period from the end of lifting to respiratory arrest or the first agonal inspiration, and the time of restitution (RT), i.e., the period from respiratory arrest to recovery of active posture. The index of hypoxic resistance was calculated as the ST/RT ratio. Its increase indicated improved resistance to extreme oxygen deficiency [2]. If ST exceeded 10 min, the animals were classified as high-resistant and the exposure was ceased. The animals with ST below 10 min were classified as low-resistant.

The neuroleptic azaleptine and its new derivative seleptine with anticonvulsive properties were examined in a chronic experiment on rabbits for their comparative effects on the spontaneous electroencephalogram (EEG) and the activation reaction in the sensorimotor cortex and dorsal hippocampus. Azaleptine induced synchronization of electroencephalographic activity in all frequency ranges of both cortical and hippocampal EEGs, while seleptine induced desynchronization in the. cortical EEG and synchronization in the 5, 0, and I~ ranges of the hippocampal EEG. Both compounds prevented the activation or altered its pattern, leading to a decrease in the power of the 13 range rather than increasing it as is normally observed.Key Words: azaleptine; seleptine; neuroleptics; anticonvulsants; total electroencephalogram; activation reaction, which has been successfully used in medical practice, is a typical neuroleptic with a unique neuropharmacological profile [4,8]. Its new structural analog seleptine (8-chloro-11-(4-methyl-1-piperazinyl)-5-acetylaminodibenzo-[b,e][1,4]-diazepine) is regarded as a potential anticonvulsant with possible psychotropic properties.In this study on rabbits, we compared the effects of the two compounds on spontaneous electric activity of the sensorimotor cortex and dorsal hippocampus as a test for alterations in the general excitability of the brain and in the functional status of neurotransmitter systems. MATERIALS AND METHODSThis chronic experiment was carried out on rabbits (bodyweight 2.3-3.5 kg), 6 animals in each group, implanted stereotaxicaUy with bipolar nichrome electrodes under Nembutal anesthesia (30 rag/ kg after Aminazine [chlorpromazine] administration). The recording electrodes were implanted into the sensorimotor area of the neocortex (AP 2-3; L 2; H 2) and into area CA3 of the dorsal hippocampus (AP 5.5-7; L 5.2-6.5; H 3.5), the stimulating electrodes were implanted into the mesencephalic part of the reticular formation (nucleus cuneiformis, pars dorsalis; AP 13.5; L 2.4; H 7), while the indifferent electrodes were placed in the nasal bone and over the visual cortex in the occipital bone. Tests were started 5-7 days postimplantation.The total electroencephalogram (EEG) was recorded bipolarly in nonrigidly fixed animals in a shielded soundproof darkened chamber. The EEG