A practical and efficient synthesis of tri-A C H T U N G T R E N N U N G azolothiadiazepine-1,1-dioxide derivatives via copper-catalyzed [3 + 2] cycloaddition, followed by N-arylation is described. The method is also applicable to the synthesis of indoline-and thiophenefused triazolothiadiazepine 1,1-dioxide derivatives.
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