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Recently, heated humidified high-flow nasal cannula (HHHFNC) has been introduced and applied as a noninvasive respiratory support in neonates. Although HHHFNC is widely used in neonates presenting with respiratory distress, the efficiency and safety when compared with nasal continuous positive airway pressure or noninvasive positive pressure ventilation are still controversial. This review aims to evaluate the performance and applications of HHHFNC in neonates.

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Background: Extracellular fluid retained in the lungs lead to respiratory distress in both late preterm (LP) and term neonates. The relationship between urine parameters toward the diuresis and the duration of ventilation postnatally is unknown. To find the correlation between the diuretic phase with urine parameters in the first 4 days after birth and the duration of non-invasive ventilation (NIV). Methods: Serial measurements of urine osmolality (Uosm), urine sodium (U Na), and urine output (U/O) in neonates were collected at 5 time periods (T1:0e12 postnatal hours, T2:12 e24 postnatal hours, T3:24e48 postnatal hours, T4:48e72 postnatal hours, T5:72e96 postnatal hours) were recorded. The correlations were analyzed in late preterm and term neonates. Results: Ninety-seven neonates were included. Negative correlation between Uosm and U/O were observed. LP neonates (nZ26) and term neonates (nZ71) had differences with Uosm at T2,