PurposeThis study aims to examine the attitudinal inconsistency among Taiwanese consumers toward organic agriculture/food, and its relationship to their willingness to pay a premium and purchase for organic product.Design/methodology/approachA telephone survey consisting of 913 households was made to reach an estimated 3.3 percent sampling error with 95 percent confidence level.FindingsIt was found that those who were female, who had higher occupation prestige, who had college education levels, who were aged in their 40s, and who possessed an optimistic opinion toward the necessity of organic farming tend to pay a premium for and buy organic food. The majority of Taiwanese respondents showed a high level of concern about pesticides but a low trust in organic food, which revealed an attitudinal inconsistency toward organic agriculture/food. A multiple discriminant analysis with a moderating variable shows that consumers' trust in organic food and their pesticide concern jointly explain the respondents' willingness to pay a premium and purchasing behavior. The influence of consumers' pesticide concern on their willingness to pay a premium and purchase actually depends on their levels of trust.Originality/valueAs a whole, lack of trust and confusing organic product certification levels is the main barrier to Taiwan's organic agriculture development. Further communication and policy modification is needed to reinforce consumers' confidence in organic agriculture/food.

Objectives Most researchers have examined forms of loneliness as discrete and emotional distress. The approach proposed in this study captures the reality that many persons experience more than one dimension of loneliness—varying degrees coupled with their psychological well-being in a family context. This study explores the latent structure of loneliness during young adulthood and its association with psychological well-being, as well as how these are related to their family characteristics in adolescence. Methods Data are from 2,748 young people, a cohort sample from the Taiwan Youth Project (TYP). Loneliness was assessed by a 6-item de Jong-Gierveld short scale with emotional and social loneliness domains. We describe the clustering between loneliness domains and psychological well-being, namely depressive symptoms, self-esteem, suicidal thoughts, and alcohol use using latent class cluster analysis. In addition to incorporating the Taiwanese family context, multivariate multinomial logistic regression models included data on family cohesion and parental guan (parental control) in adolescence. This might be associated with choices in partnership and childbearing, and influence loneliness in young adulthood. Results Our results demonstrate a three-cluster model of loneliness involving emotional loners, serious emotional loners, and severe emotional/social loners. We also found that a feeling of serious emotional loneliness and severe emotional/social loneliness were significantly associated with psychological well-being, even adjusting for individual characteristics. Among young adults who had a partner, the married adults were significantly less likely to feel serious emotional loneliness than those who were living alone. Furthermore, young adults with stronger family cohesion during early adolescence were less likely to suffer from serious emotional loneliness (Relative risk ratios [RRR] 0.77, 95% CI 0.65–0.91) and severe emotional/social loneliness (RRR 0.54, 95% CI 0.34–0.85) in young adulthood. Discussion This measurement strategy provides a foundation for future research into how experts can address loneliness clusters in order to better understand psychological well-being during young adulthood and family context in adolescence. This is important because our results suggest that the various loneliness domains do not occur independently, but rather are embedded in patterns and are associated with family characteristics.

Paeonol is a major phenolic compound of the Chinese herb, Cortex Moutan, and is known for its antioxidant, anti-inflammatory and antitumor properties. The present study was designed to investigate the therapeutic potential and underlying mechanisms of paeonol on a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/p)-induced mouse model of Parkinson's disease (PD). MPTP (25 mg/kg), followed by probenecid (250 mg/kg), was administered via i.p. injection for five consecutive days to induce the mouse model of PD. Paeonol (20 mg/kg) was administrated orally for 21 days. Behavior was assessed using the rotarod performance and open-field tests. Additionally, the levels of tyrosine hydroxylase (TH), microglia, interleukin-1β (IL-1β), and brain-derived neurotrophic factor (BDNF) in the substantia nigra pars compacta (SNpc) were evaluated by immunohistochemical staining. MPTP/p-induced motor deficits were observed to be significantly improved following long-term treatment with paeonol. Paeonol treatment decreased MPTP/p-induced oxidative stress, as determined by evaluating the activity levels of superoxide dismutase, catalase and glutathione. Additionally, MPTP/p-induced neuroinflammation was assessed by examining the levels of microglia and IL-1β, which were significantly decreased following paeonol treatment. Paeonol treatment improved the MPTP/p-induced dopaminergic neurodegeneration, as measured by observing the increased TH level in the SNpc. Furthermore, the BDNF level was significantly elevated in the paeonol treatment group compared with mice treated with MPTP/p only. In conclusion, paeonol exerted therapeutic effects in the MPTP/p-induced mouse model of PD, possibly by decreasing the damage from oxidative stress and neuroinflammation, and by enhancing the neurotrophic effect on dopaminergic neurons. The results demonstrate paeonol as a potential novel treatment for PD.

Cerebral angiogenesis is a key event during brain development and recovery from brain injury. We previously demonstrated that Atg7 knockout impaired angiogenesis in the mouse brain. However, the role of Atg7 in angiogenesis is not completely understood. In this study, we used human brain microvascular endothelial cells (HBMECs) to investigate the mechanism of Atg7‐regulated cerebral angiogenesis. We found that Atg7 depletion specifically diminished the expression of the β3 and γ2 chains of laminin‐5, a major component of the extracellular matrix. In contrast, autophagy inhibitors did not affect laminin‐5 expression, suggesting that Atg7‐regulated laminin‐5 expression is autophagy‐independent. We also found that Atg7‐regulated laminin‐5 expression occurred at the transcriptional level through NF‐κB signaling. Exogenous laminin‐5 or the NF‐κB agonist betulinic acid effectively rescued tube formation by Atg7‐deficient HBMECs. Taken together, our study identified a novel mechanism by which Atg7 regulates laminin‐5 expression via NF‐κB to modulate tube formation by brain endothelial cells during cerebral angiogenesis. Anat Rec, 302:2255–2260, 2019. © 2019 American Association for Anatomy

No abstract