No abstract

In recent years, there has been increasing interest in using hypertonic and hyperoncotic solutions for the treatment of hemorrhagic hypotension [1][2][3][4][5][6][7][8][9], which is explained by the high level of lethality caused by this factor.Experiments on test animals following a heavy hemorrhagic shock, resuscitated by infusing a small volume (10% of the total blood loss) of a 7.5% sodium chloride solution showed that this way offers a promising clinical method. The treatment led to a rapid growth in the systemic medal pressure (AP), recovery of the heart beat, and increase ha the survival of test animals in 100% of cases [10][11][12][13].The principal mechanism of the therapeutic effect of the "small-scale" resuscitation amounts essentially to artificial stimulation of the autohemodilution rhythm with a hypertonic salt solution, that is, to activation of the process of intrinsic liquid mobilization in the interstitial volume and its supply to the vascular bed. Unfortunately, the therapeutic action of the hyperosmolar solutions introduced into the organism has a rather short duration. In order to increase the period of maintaining the intravaseular blood volume on a sufficiently high level, the infusion of a 7.5% sodium chloride solution is combined with the introduction of a colloidal solution of dextran or hydroxyethyl starch. This combination simultaneously increases the plasma osmolarity and maintains its oneotic pressure.The purpose of this work was to assess the therapeutic effect of substituting a small volume of the new antishock drug hemostabil for a largevolume blood loss (45 ml/kg) in dogs. The drug hemostabil, currently in the preclinical investigation stage, comprises the mixture of a 7.5% sodium chloride solution and a 10% rheopolyglucin solution. The fundamental interest ha and practical importance of this study are related to the fact that a more or less effective therapy is usually possible neither at the site of accident nor during the transportation of patients. Indeed, the compensation for a large-volume blood loss, for example, with a