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Background: Pancreatic ductal adenocarcinoma (PADA) represents a devastating type of pancreatic cancer with high mortality. Defining a prognostic gene signature that can stratify patients with different risk will benefit cancer treatment strategies. Methods: Gene expression profiles of PADA patients were acquired from the Cancer Genome Atlas and Gene Expression Omnibus, including GSE62452 and GSE28735. Differential expression analysis was carried out using the package edgeR in R. Intro-tumor immune infiltrates were quantified by six different computational algorithms XCELL, TIMER, QUANTISEQ, MCPCOUNTER, EPIC, and CIBERSORT. Biological processes were investigated based on R package "clusterProfiler". Results: 13 genes (ARNTL2,

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A new type of composite foundation, named concrete-cored sand-gravel pile composite foundation for thick and soft ground treatment is introduced in this paper. The new style composite foundation is composed of the concrete-cored sand-gravel pile, the soil between piles and the cushion. This paper describes its design and construction technology, and analyzes its load transfer mode and improvement mechanism . Field test results indicate that the new type combined pile is sufficient in satisfying the stability and the post-construction settlement of embankment and foundation.